BIBU 1361 DIHYDROCHLORIDE
- Product Name
- BIBU 1361 DIHYDROCHLORIDE
- CAS No.
- 793726-84-8
- Chemical Name
- BIBU 1361 DIHYDROCHLORIDE
- Synonyms
- BIBU 1361;BIBU1361 (BIBU 1361 );BIBU 1361 DIHYDROCHLORIDE;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]pyrimido[5,4-d]pyrimidin-4-amine;Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride;N-(3-CHLORO-4-FLUOROPHENYL)-6-[4-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]-PYRIMIDO[5,4-D]PYRIMIDIN-4-AMINE DIHYDROCHLORIDE
- CBNumber
- CB0840882
- Molecular Formula
- C22H27ClFN7
- Formula Weight
- 443.95
- MOL File
- 793726-84-8.mol
BIBU 1361 DIHYDROCHLORIDE Property
- Boiling point:
- 580.0±60.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 10.32±0.25(Predicted)
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- 2417
- Product name
- BIBU1361dihydrochloride
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 254751
- Product name
- BIBU 1361 dihydrochloride
- Packaging
- 1mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- B7048
- Product name
- BIBU1361dihydrochloride
- Packaging
- 10mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- KIN0000049
- Product name
- BIBU 1361 DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $636.7
- Updated
- 2021/12/16
- Product number
- KIN0000049
- Product name
- BIBU 1361 DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $757.97
- Updated
- 2021/12/16
BIBU 1361 DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
BIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μ M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
References
[1]. antczak c, mahida jp, bhinder b, et al. a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function implications in drug discovery. journal of biomolecular screening, 2012, 17(7): 885-899.
[2]. ghildiyal r, dixit d, sen e. egfr inhibitor bibu induces apoptosis and defective autophagy in glioma cells. molecular carcinogenesis, 2013, 52(12): 970-982.