6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE

Application

Product Name: 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE
CAS No.: 28279-49-4
Chemical Name: 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE
Synonyms: 5-Bromo-7-azabenzimidazole;6-Bromo-4-azabenzimidazole;6-Bromo-4H-imidazo[4,5-b]...;6-Bromoimidazo[4,5-b]pyridine;6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE;6-BROMO-4H-IMIDAZO[4,5-B]PYRIDINE;3H-IMidazo[4,5-b]pyridine, 6-broMo-;6-Bromo-3H-imidazo[4,5-b]pyridine 96%;6-Bromo-4-azabenzimidazole;1H-Imidazo[4,5-b]pyridine,6-bromo-(8CI,9CI)
CBNumber: CB0841430
Molecular Formula: C6H4BrN3
Formula Weight: 198.02
MOL File: 28279-49-4.mol

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6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE Property

Melting point:: 227-228℃ (water )
Boiling point:: 218.4±50.0 °C(Predicted)
Density: 2.00±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 7.02±0.20(Predicted)
color: Light brown
InChI: InChI=1S/C6H4BrN3/c7-4-1-5-6(8-2-4)10-3-9-5/h1-3H,(H,8,9,10)
InChIKey: XPHWCAKVRKUXLK-UHFFFAOYSA-N
SMILES: C12NC=NC1=CC(Br)=CN=2

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 732273
Product name: 6-Bromo-4-azabenzimidazole
Purity: 95%
Packaging: 1g
Price: $488
Updated: 2023/06/20

TRC

Product number: B696313
Product name: 6-Bromo-1h-imidazo[4,5-b]pyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696313
Product name: 6-Bromo-1h-imidazo[4,5-b]pyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB76803
Product name: 6-Bromo-1H-imidazo[4,5-b]pyridine
Packaging: 1g
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB76803
Product name: 6-Bromo-1H-imidazo[4,5-b]pyridine
Packaging: 2g
Price: $64
Updated: 2021/12/16

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6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE Chemical Properties,Usage,Production

Application

Literature reports that 6-bromo-3H-imidazo[4,5-B]pyridine can be used to prepare inhibitors targeting the PI3K-AKT-mTOR signaling pathway, such as 2-[4-[8-(3H)imidazo[4,5-b]pyridin-6-yl)-3-methyl-1H-pyrazole[4,3-c]quinoline-1-yl]phenyl]-2-methylpropionitrile.

Synthesis

38875-53-5

64-18-6

28279-49-4

The reaction was carried out with 2,3-diamino-5-bromopyridine (1.00 g, 5.32 mmol) and formic acid (0.5 mL) in 15 mL of triethyl orthoformate with stirring for 3 h at 100 °C. The reaction was carried out by LC-MS. The reaction progress was monitored by LC-MS, and after confirming the completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: 10% methanol/dichloromethane) to afford 6-bromo-4H-imidazo[4,5-B]pyridine (1.01 g, 96% yield) as a beige solid.1H NMR (400 MHz, DMSO-d6) δ 8.46 (s, 1H), 8.41 (d, 1H), 8.27 (d, 1H).

References

[1] Patent: WO2008/82487, 2008, A2. Location in patent: Page/Page column 107
[2] Patent: WO2016/142310, 2016, A1. Location in patent: Page/Page column 86-87
[3] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0737
[4] Patent: WO2009/42607, 2009, A1. Location in patent: Page/Page column 72
[5] Patent: WO2007/127183, 2007, A1. Location in patent: Page/Page column 140-141

6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE Suppliers

China 118 Europe 1 France 1 Germany 2 India 3 Russia 1 United Kingdom 6 United States 18 Global 150

ShangHai AmK Pharmaceutical Technology Co., Ltd.

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View Lastest Price from 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE manufacturers

Dideu Industries Group Limited

Product: 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE 28279-49-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE 28279-49-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE 28279-49-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

28279-49-4, 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINERelated Search:

6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE 6-BROMO-2-METHYL-4H-IMIDAZO[4,5-B]PYRIDINE 6-BROMO-2-CHLOROMETHYL-IMIDAZO[1,2-A]PYRIDINE 3H-Imidazo[4,5-b]pyridine, 6-bromo-, 4-oxide 6-Bromo-2-trifluoromethyl-3H-imidazo[4,5-b]pyridine 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE-5-CARBOXYLIC ACID 6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE-7-CARBOXYLIC ACID 6-BROMO-2-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE 6-bromo-5-methyl-1H-imidazo[4,5-b]pyridine 6-BROMO-1H-IMIDAZO[4,5-B]PYRIDINE-2(3H)-THIONE 6-BROMO-2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 6-BROMO-3-PHENYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 6-BROMO-2-PHENYL-IMIDAZO[1,2-A]PYRIDINE 7-Bromo-1H-imidazo[4,5-c]pyridine 5-BROMO-3-IODO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 1-Bromo-3-methyl-imidazo[1,5-a]pyridine 2-bromo-6-iodoH-imidazo[1,2-a]pyridine 2-bromo-7-chloroH-imidazo[1,2-a]pyridine

6-Bromo-3H-imidazo[4,5-b]pyridine 96%

1H-Imidazo[4,5-b]pyridine,6-bromo-(8CI,9CI)

6-BROMO-4H-IMIDAZO[4,5-B]PYRIDINE

6-Bromoimidazo[4,5-b]pyridine

6-Bromo-4H-imidazo[4,5-b]...

6-Bromo-4-azabenzimidazole

3H-IMidazo[4,5-b]pyridine, 6-broMo-

6-Bromo-1H-imidazo[4,5-b]pyridine 6-Bromo-3H-imidazo[4,5-b]pyridine

5-Bromo-7-azabenzimidazole

6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE

6-BROMO-3H-IMIDAZO[4,5-B]PYRIDINE ISO 9001：2015 REACH

6-Bromo-4-azabenzimidazole

6-Bromo-3H-imidazo[4,5-b]pyridine

28279-49-4

Heterocycle-Pyridine series

PYRIDINE

Halides

Fused Ring Systems