5-Bromo-1-methyl-2-oxoindoline
- Product Name
- 5-Bromo-1-methyl-2-oxoindoline
- CAS No.
- 20870-90-0
- Chemical Name
- 5-Bromo-1-methyl-2-oxoindoline
- Synonyms
- -2-oxoindoL;5-bromo-1-methyl-oxindole;5-Bromo-1-methyl-2-oxindole;5-bromo-1-methyl-2-indolinone;5-broMo-1-Methylindolin-2-one;1-Methyl-5-bromoindolin-2-one;5-Bromo-1-methyl-2-oxindole97%;5-Bromo-1-methyl-2-oxoindoline;5-bromo-1-methyl-3H-indol-2-one;5-Bromo-1-methyl-2-oxindole 97%
- CBNumber
- CB0853321
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 20870-90-0.mol
5-Bromo-1-methyl-2-oxoindoline Property
- Melting point:
- 132 °C
- Boiling point:
- 418.1±45.0 °C(Predicted)
- Density
- 1.589±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.51±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 20870-90-0
Safety
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697413
- Product name
- 5-Bromo-1-methyl-2-oxoindoline
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- 4H48-9-Y8
- Product name
- 5-Bromo-1-methyl-2-oxindole
- Purity
- 97%
- Packaging
- 5G
- Price
- $416
- Updated
- 2021/12/16
- Product number
- FB118874
- Product name
- 5-Bromo-1-methyl-1,3-dihydro-2H-indol-2-one
- Packaging
- 2g
- Price
- $434
- Updated
- 2021/12/16
- Product number
- Y8209
- Product name
- 5-Bromo-1-methylindolin-2-one
- Packaging
- 5g
- Price
- $477
- Updated
- 2021/12/16
- Product number
- FB118874
- Product name
- 5-Bromo-1-methyl-1,3-dihydro-2H-indol-2-one
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
5-Bromo-1-methyl-2-oxoindoline Chemical Properties,Usage,Production
Uses
5-Bromo-1-methyl-2-oxoindoline is a useful intermediate for organic synthesis. It is used as an intermediate in the preparation of symmetric cyclic indole-tetramers and some substituted oxindoles.
Synthesis
61-70-1
20870-90-0
General procedure for the synthesis of 5-bromo-1-methyl-2-oxodihydroindole from 1-methyl-2-indolinone: N-methylindole (0.5 g, 3.4 mmol) was dissolved in acetonitrile (5 mL) and stirred at 0 °C. Subsequently, N-bromosuccinimide (NBS, 0.62 g) dissolved in acetonitrile (10 mL) was added slowly and dropwise. The reaction mixture was kept stirred at 0 °C for 1 h, followed by continued stirring for 2 h at room temperature. After completion of the reaction, the solvent was removed by rotary evaporation and the resulting solid was dissolved in chloroform (CHCl3) and washed twice with deionized water. After removing the chloroform again by rotary evaporation, the resulting brown solid was recrystallized with hexane to give 5-bromo-N-methylhydroxyindole (0.44 g, 58% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3) with the following chemical shifts δ (ppm): 7.42-7.39 (d, 1H), 7.26 (s, 1H), 6.71-6.68 (d, 1H), 3.52-3.20 (s, 2H), 3.19 (s, 3H).
References
[1] European Journal of Organic Chemistry, 2011, # 20-21, p. 3781 - 3793
[2] RSC Advances, 2016, vol. 6, # 74, p. 70221 - 70225
[3] Molecular Crystals and Liquid Crystals, 2015, vol. 618, # 1, p. 47 - 54
[4] Journal fuer Praktische Chemie (Leipzig), 1930, vol. <2>128, p. 1,23
5-Bromo-1-methyl-2-oxoindoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-1-methyl-2-oxoindoline manufacturers
- Product
- 5-BROMO-1-METHYL-2-OXOINDOLINE 20870-90-0
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-26