ChemicalBook > CAS DataBase List > (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
- Product Name
- (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
- CAS No.
- 139226-28-1
- Chemical Name
- (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one
- Synonyms
- CS-490;darbufelone;Darbufelone, 10 mM in DMSO;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl);(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide...;(Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one;5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one;(5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one;4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-
- CBNumber
- CB0855486
- Molecular Formula
- C18H24N2O2S
- Formula Weight
- 332.46
- MOL File
- 139226-28-1.mol
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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Property
- Boiling point:
- 448.6±55.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 9.98±0.50(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0021331
- Product name
- Darbufelone
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $240
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0005639
- Product name
- DARBUFELONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.07
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0005639
- Product name
- DARBUFELONE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2047.5
- Updated
- 2021/12/16
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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Chemical Properties,Usage,Production
Biological Activity
Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. It potently inhibits PGHS-2 (IC50=0.19 μM), but is much less potent against PGHS-1 (IC50=20 μM).
in vivo
Darbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis.
target
IC50: 0.19 μM (PGHS-2), 20 μM (PGHS-1)
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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139226-28-1, (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-oneRelated Search:
Phenol
Thiazole
DARBUFELONE MESILATE
(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one