Bilaid C
- Product Name
- Bilaid C
- CAS No.
- 2393866-13-0
- Chemical Name
- Bilaid C
- Synonyms
- Bilaid C;L-tyrosyl-D-valyl-L-valyl-D-phenylalanine;D-Phenylalanine, L-tyrosyl-D-valyl-L-valyl-
- CBNumber
- CB08571023
- Molecular Formula
- C28H38N4O6
- Formula Weight
- 526.62
- MOL File
- 2393866-13-0.mol
Bilaid C Property
- Boiling point:
- 866.4±65.0 °C(Predicted)
- Density
- 1.222±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 3.50±0.10(Predicted)
- form
- A solid
- Sequence
- Tyr-{D-Val}-Val-{D-Phe}
Bilaid C Chemical Properties,Usage,Production
Uses
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr)[1].
Biological Activity
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki = 210 nM in HEK293 cell membranes expressing the human receptor) that has been found in Penicillium.1 It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human μ-opioid receptor when used at a concentration of 10 μM. Bilaid C induces inward rectifying potassium channel (Kir) currents in rat locus coeruleus slices that endogenously express high levels of the μ-opioid receptor (EC50 = 4.2 μM).
IC 50
human μ-opioid receptor: 210 nM (Ki)
References
1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019)
Bilaid C Preparation Products And Raw materials
Raw materials
Preparation Products
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