Isoconazole

ChemicalBook > CAS DataBase List > Isoconazole

Product Name: Isoconazole
CAS No.: 27523-40-6
Chemical Name: Isoconazole
Synonyms: Isoconazol;soconazole;Isoconazole CRS;Einecs 248-508-3;Miconazole EP IMP D;24168-96-5 (Nitrate);Miconazole Impurity D;Isoconazole USP/EP/BP;Isoconazol [inn-spanish];Miconazole EP Impurity D
CBNumber: CB0875200
Molecular Formula: C18H14Cl4N2O
Formula Weight: 416.13
MOL File: 27523-40-6.mol

Less

Isoconazole Property

Boiling point:: 555.1±50.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).
pka: 6?+-.0.12(Predicted)
CAS DataBase Reference: 27523-40-6

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I0375000
Product name: Isoconazole
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: i0375000
Price: $220
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0007221
Product name: ISOCONAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $544.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007221
Product name: ISOCONAZOLE
Purity: 95.00%
Packaging: 10MG
Price: $939.75
Updated: 2021/12/16

Less

Isoconazole Chemical Properties,Usage,Production

Chemical Properties

White or almost white powder.

Originator

Fazol,Fournier,France,1979

Uses

Antibacterial; antifungal.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, isoconazole is indicated for therapy of vulvovaginal mycoses causes by Candida species and Candida (Torulopsis) glabrata.

Definition

ChEBI: 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether and a member of imidazoles.

Manufacturing Process

To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.

Therapeutic Function

Antibacterial, Antifungal

Antimicrobial activity

Broad-spectrum azole antimycotic with activity against almost all species of pathogenic fungi.

Pharmacokinetics

After topical application, isoconazole remains practically unabsorbed. Application in an ethanol/propyleneglycol vehicle increases penetration into the stratum corneum of the skin significantly.

Side effects

Local irritations such as itching and burning sensations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Solubility in organics

Isoconazole is soluble in methanol, acetic acid, and PEG 400; less soluble in ethanol, acetone, chloroform, and butanol; and barely soluble in water, diethyl ether, cyclohexane, and hexane.

Isoconazole Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Isoconazole Suppliers

China 67 Germany 1 India 6 South Korea 1 United Kingdom 1 United States 6 Global 82

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7850
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5113
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6116
Advantage: 58

Shanghai CR Corporation Limited

Tel: 021-80270511; 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 10044
Advantage: 58

Zhuhai JiaYi Biological Technology Co., Ltd.

Tel: 18578209868 2355327026
Fax: 18578209868 QQ：2355327026
Email: steroidbest@hotmail.com
Country: China
ProdList: 6501
Advantage: 58

Foshan DaoQi Biological Co., Ltd.

Tel: 18062666947
Fax: 18062666959
Email: 2355880548@qq.com
Country: China
ProdList: 4228
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4391
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7781
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8647
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22883
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30240
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 17825480238
Fax: QQ 3008233717
Email: 3008233717@qq.com
Country: China
ProdList: 9919
Advantage: 12

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17365
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14246
Advantage: 58

Shanghai Lanc Pharmaceutical Technology Co., Ltd.

Tel: 021-52216295 lankepharma
Email: 3813332848@qq.com
Country: China
ProdList: 523
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Hubei MAX Fine Chemical Technology Co., Ltd.

Tel: 13026126800 13027176014
Fax: QQ1652805836
Email: hbmaxkj@163.com
Country: China
ProdList: 4728
Advantage: 58

Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.

Tel: 027-59225746 18062681621
Fax: 027-59225746
Email: 730880265@qq.com
Country: China
ProdList: 4785
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4495
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6567
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3006
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9996
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Country: China
ProdList: 24326
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6886
Advantage: 58

Scinova Biotech(Guangzhou) Co., Ltd.

Tel: 13268215580
Email: scinova_sales@163.com
Country: China
ProdList: 7023
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7735
Advantage: 58

Shaanxi Dideu Newmaterial Co., Ltd.

Tel: 029-87576359 15353716720
Email: 1039@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Shanghai YuZn Pharm. Technology Co.,Ltd.

Tel: 15921286451; 15921286451
Email: 2010681527@qq.com
Country: China
ProdList: 5095
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 3273
Advantage: 58

Nanjing Huanuo Biomedical Technology Co., Ltd

Tel: 18913906212
Email: 2885426135@qq.com
Country: China
ProdList: 7202
Advantage: 58

Tan-Mo Technology Co., Ltd.

Tel: 19850211281
Email: qiann@gbw-china.com
Country: China
ProdList: 1980
Advantage: 58

Shanghai Zerui Biotechnology Co., Ltd.

Tel: 021-54580889 18321124657
Fax: 021-54580889
Email: 731997554@qq.com
Country: China
ProdList: 10608
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb5@aikonchem.com
Country: China
ProdList: 10528
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13070690626
Email: admin@mopaikeji.com
Country: China
ProdList: 10756
Advantage: 58

Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd

Tel: 18502726233; 18502726233
Email: 3641133981@qq.com
Country: China
ProdList: 9706
Advantage: 58

Henan Vcommend Consultrading Co., Ltd.

Tel: 13393721940
Email: sales@vcommend.com
Country: China
ProdList: 9962
Advantage: 58

Shanghai Aitixi Biotechnology Co., Ltd

Tel: 18721763493 18721763493
Email: 2493172863@qq.com
Country: China
ProdList: 1009
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 30961
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9763
Advantage: 58

Less

View Lastest Price from Isoconazole manufacturers

Dideu Industries Group Limited

Product: Isoconazole 27523-40-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-19

27523-40-6, IsoconazoleRelated Search:

Miconazole Impurity Miconazole IMpurity B Miconazole IMpurity H AMMONIUM TUNGSTATE 99.99% Ketoconazole Itraconazole Posaconazole Econazole alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Econazole nitrate Miconazole IMpurity I 2,4-Dichlorobenzyl alcohol Miconazole EP IMpurity C Miconazole EP Impurity F MilbeMycin A4 OxiMe Milrinone Impurity 13 Milbemycin EP Impurity D Milbemycin oxime

Miconazole Impurity 4(Miconazole EP Impurity D)

1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]- (9CI)

Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]- (8CI)

Isoconazole (base and/or unspecified salts)

1-(2,4-Dichlorophenyl)-1-[(2,6-dichlorophenyl)methoxy]-2-(1H-imidazole-1-yl)ethane

1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,6-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[β-[(2,6-Dichlorobenzyl)oxy]-2,4-dichlorophenethyl]-1H-imidazole

1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-

24168-96-5 (Nitrate)

Einecs 248-508-3

Imidazole, 1-(2,4-dichloro-beta-((2,6-dichlorobenzyl)oxy)phenethyl)- (8ci)

Isoconazol

Isoconazol [inn-spanish]

soconazole

1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole

Miconazole Impurity D

Miconazole EP IMP D

Miconazole Nitrate EP Impurity D

Miconazole EP Impurity D

Isoconazole CRS

Isoconazole (Miconazole EP Impurity D)

Isoconazole USP/EP/BP

Miconazole EP impurity DQ: What is Miconazole EP impurity D Q: What is the CAS Number of Miconazole EP impurity D Q: What is the storage condition of Miconazole EP impurity D Q: What are the applications of Miconazole EP impurity D

1-2-(2,4-dichlorophenyl)-2-(2,6-dichlorophenyl)methoxyethylimidazole (Isoconazole)

Miconazole EP Impurity D (Isoconazole)

27523-40-6