Isoconazole

ChemicalBook > CAS DataBase List > Isoconazole

Product Name: Isoconazole
CAS No.: 27523-40-6
Chemical Name: Isoconazole
Synonyms: Isoconazol;soconazole;Isoconazole CRS;Einecs 248-508-3;Miconazole EP IMP D;24168-96-5 (Nitrate);Miconazole Impurity D;Isoconazole USP/EP/BP;Isoconazol [inn-spanish];Miconazole EP Impurity D
CBNumber: CB0875200
Molecular Formula: C18H14Cl4N2O
Formula Weight: 416.13
MOL File: 27523-40-6.mol

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Isoconazole Property

Boiling point:: 555.1±50.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).
pka: 6?+-.0.12(Predicted)
CAS DataBase Reference: 27523-40-6

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I0375000
Product name: Isoconazole
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: i0375000
Price: $220
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0007221
Product name: ISOCONAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $544.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007221
Product name: ISOCONAZOLE
Purity: 95.00%
Packaging: 10MG
Price: $939.75
Updated: 2021/12/16

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Isoconazole Chemical Properties,Usage,Production

Chemical Properties

White or almost white powder.

Originator

Fazol,Fournier,France,1979

Uses

Antibacterial; antifungal.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, isoconazole is indicated for therapy of vulvovaginal mycoses causes by Candida species and Candida (Torulopsis) glabrata.

Definition

ChEBI: 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether and a member of imidazoles.

Manufacturing Process

To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.

Therapeutic Function

Antibacterial, Antifungal

Antimicrobial activity

Broad-spectrum azole antimycotic with activity against almost all species of pathogenic fungi.

Pharmacokinetics

After topical application, isoconazole remains practically unabsorbed. Application in an ethanol/propyleneglycol vehicle increases penetration into the stratum corneum of the skin significantly.

Side effects

Local irritations such as itching and burning sensations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Solubility in organics

Isoconazole is soluble in methanol, acetic acid, and PEG 400; less soluble in ethanol, acetone, chloroform, and butanol; and barely soluble in water, diethyl ether, cyclohexane, and hexane.

Isoconazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isoconazole manufacturers

Dideu Industries Group Limited

Product: Isoconazole 27523-40-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-19

Shaanxi Dideu Medichem Co. Ltd

Product: Isoconazole 27523-40-6
Price: US $0.01-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-05-12

27523-40-6, IsoconazoleRelated Search:

Miconazole Impurity Miconazole IMpurity B Miconazole IMpurity H AMMONIUM TUNGSTATE 99.99% Ketoconazole Itraconazole Posaconazole Econazole alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Econazole nitrate Miconazole IMpurity I 2,4-Dichlorobenzyl alcohol Miconazole EP IMpurity C Miconazole EP Impurity F MilbeMycin A4 OxiMe Milrinone Impurity 13 Milbemycin EP Impurity D Milbemycin oxime

Miconazole Impurity 4(Miconazole EP Impurity D)

1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]- (9CI)

Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]- (8CI)

Isoconazole (base and/or unspecified salts)

1-(2,4-Dichlorophenyl)-1-[(2,6-dichlorophenyl)methoxy]-2-(1H-imidazole-1-yl)ethane

1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,6-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[β-[(2,6-Dichlorobenzyl)oxy]-2,4-dichlorophenethyl]-1H-imidazole

1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-

24168-96-5 (Nitrate)

Einecs 248-508-3

Imidazole, 1-(2,4-dichloro-beta-((2,6-dichlorobenzyl)oxy)phenethyl)- (8ci)

Isoconazol

Isoconazol [inn-spanish]

soconazole

1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole

Miconazole Impurity D

Miconazole EP IMP D

Miconazole Nitrate EP Impurity D

Miconazole EP Impurity D

Isoconazole CRS

Isoconazole (Miconazole EP Impurity D)

Isoconazole USP/EP/BP

Miconazole EP impurity DQ: What is Miconazole EP impurity D Q: What is the CAS Number of Miconazole EP impurity D Q: What is the storage condition of Miconazole EP impurity D Q: What are the applications of Miconazole EP impurity D

1-2-(2,4-dichlorophenyl)-2-(2,6-dichlorophenyl)methoxyethylimidazole (Isoconazole)

27523-40-6