gemeprost
- Product Name
- gemeprost
- CAS No.
- 64318-79-2
- Chemical Name
- gemeprost
- Synonyms
- D02073;Cergem;ONO 802;Carprost;Cervagem;SC 37681;Cervageme;gemeprost;Preglandin;Preglandin (tn)
- CBNumber
- CB0875558
- Molecular Formula
- C23H38O5
- Formula Weight
- 394.548
- MOL File
- 64318-79-2.mol
gemeprost Property
- Boiling point:
- 438.73°C (rough estimate)
- Density
- 1.0380 (rough estimate)
- refractive index
- 1.5800 (estimate)
- pka
- 13.84±0.60(Predicted)
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H312Harmful in contact with skin
H332Harmful if inhaled
H360May damage fertility or the unborn child
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- G305040
- Product name
- Gemeprost
- Packaging
- 5mg
- Price
- $2810
- Updated
- 2021/12/16
- Product number
- API0002815
- Product name
- GEMEPROST
- Purity
- 95.00%
- Packaging
- 500ML
- Price
- $4138.37
- Updated
- 2021/12/16
- Product number
- API0002815
- Product name
- GEMEPROST
- Purity
- 95.00%
- Packaging
- 5ML
- Price
- $787.71
- Updated
- 2021/12/16
- Product number
- 18648
- Product name
- Gemeprost
- Packaging
- 5mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- API0002815
- Product name
- GEMEPROST
- Purity
- 95.00%
- Packaging
- 100ML
- Price
- $2365.44
- Updated
- 2021/12/16
gemeprost Chemical Properties,Usage,Production
Description
Gemeprost, a metabolically stabilized analog of PGE1, has been demonstrated to reliably induce termination of early pregnancy when administered as a vaginal suppository. Its effect is presumably due to both uterine contraction and rapid decline of steroid hormone levels. Minimal side effects have been reported.
Originator
Ono (Japan)
Uses
Gemeprost is an analogue of Prostaglandin (P838600). Gemeprosts, similarly to Nitric Oxide donors, induce uterine cervical dilation and are used before surgical termination of pregnancy.
Uses
Prostaglandin.
Definition
ChEBI: Gemeprost is an aliphatic alcohol.
Manufacturing Process
Synthesis of 9-oxo-1α,15α-bis-(2-tetrahydropyranyloxy)-16,16-dimethylprosta-trans-2, trans-13-dienoic acid: 4 g of ethyl 9α-hydroxy-11α15α-bis-(2-
tetrahydropyranyloxy)-16,16-dimethyl-prosta-trans-2,trans-13-dienoate were
dissolved in 130 ml of a mixture of ethanol-water (3:1), mixed with 3.9 g of
potassium hydroxide and stirred at 25°C for 2 hours. The reaction mixture
was acidified with aqueous solution of oxalic acid to pH 5, and diluted with
100 ml of water, extracted with ethyl acetate. The extracts were washed with
water, dried over sodium sulfate and concentrated under reduced pressure to
obtain 3.88 g of 9α-hydroxy-11α,15α-bis-(2-tetrahydropyranyloxy)-16,16-
dimethyl-prosta-trans-2,trans-13dienoic acid.
The obtained compound 2.46 g were dissolved in 72 ml of diethyl ether and
stirred at 3°C. To which a solution of manganese sulfate (15 g), 3.1 g of
chromium trioxide, 72 ml of water and 3.5 ml of sulfuric acid was added. After
stirring for 3.5 hours at 3°C, extracted with diethyl ether. The organic layer
was washed with water, dried over sodium sulfate and concentrated under
reduced pressure. The residue was purified by column chromatography on
silica gel using ethyl acetate-benzene (1:1) as eluent to give 2.35 g of the
title compound.
Synthesis of 16,16-dimethyl-trans-δ2-PGE1: 2.35 g of the bistetrahydropyranyl ether were dissolved in 6 ml of tetrahydrofuran and 60 ml
of 65%-acetic acid aqueous solution and the solution stirred at 60°C to 70°C
for 20 minutes. The reaction mixture was extracted with ethyl acetate, and
the organic layer was washed with water, dried and concentrated under
reduced pressure. The residue was purified by column chromatography on
silica gel using ethyl acetate-cyclohexane (2:3) as eluent to yield 270 mg of
the title compound.
brand name
CERVAGEM
Therapeutic Function
Prostaglandin, Cervical softener
gemeprost Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from gemeprost manufacturers
- Product
- gemeprost 64318-79-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-07-09