Dantrolene

Product Name: Dantrolene
CAS No.: 7261-97-4
Chemical Name: Dantrolene
Synonyms: C06939;DANTRILENE;Dantrolene (200 mg);Dantrolene (1163140);1-[5-(4-Nitrophenyl)-2-furylmethyleneamino]imidazolidine-2,4-dione;1-{(5-(4-NITROPHENYL)-2-FURANYL)METHYLENE}AMINO-2,4-IMIDAZOLIDENEDIONE;1-{[5-(4-nitrophenyl)-2-furyl]methylideneamino} imidazolidine-2,4-dione;1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione;1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione;2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-
CBNumber: CB0875659
Molecular Formula: C14H10N4O5
Formula Weight: 314.25
MOL File: 7261-97-4.mol

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Dantrolene Property

Melting point:: 279-280°
Boiling point:: 453.94°C (rough estimate)
Density: 1.3452 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Store at -20°C
solubility: DMSO (Slightly), Methanol (Very Slightly, Sonicated)
pka: 7.68±0.10(Predicted)
form: Solid
color: Yellow to Dark Yellow
Stability:: Hygroscopic
EPA Substance Registry System: Dantrolene (7261-97-4)

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Safety

HS Code: 2934990002
Hazardous Substances Data: 7261-97-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2291
Product name: Dantrolene
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging: 500MG
Price: $186
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1163140
Product name: Dantrolene
Packaging: 200mg
Price: $480
Updated: 2024/03/01

TRC

Product number: D184995
Product name: Dantrolene
Packaging: 100mg
Price: $215
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009178
Product name: DANTROLENE
Purity: 95.00%
Packaging: 1G
Price: $745.5
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18586
Product name: Dantrolene
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

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Dantrolene Chemical Properties,Usage,Production

Originator

Dantrium,Norwich Eaton ,US,1974

Uses

Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.

Uses

Relaxant (skeletal muscle).

Definition

ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.

Manufacturing Process

5-(p-Nitrophenyl)-2-furaldehyde (40.0 grams, 0.2 mol) is dissolved in dimethylformamide. An aqueous solution of 1-aminohydantoin hydrochloride (30.0 grams, 0.2 mol) is added. The solution is chilled and diluted with water. The crude material is collected and recrystallized from aqueous dimethylformamide to yield 10.0 grams (16%). MP 279°-280°C. This compound is then converted to the sodium salt.

brand name

Dantrium (Procter & Gamble).

Therapeutic Function

Muscle relaxant

General Description

Crystals (in aqueous DMF).

Air & Water Reactions

Slightly water soluble. Dantrolene may be sensitive to heat and air .

Reactivity Profile

A nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever.

Fire Hazard

Flash point data for Dantrolene are not available. Dantrolene is probably combustible.

Dantrolene Preparation Products And Raw materials

Raw materials

Preparation Products

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Dantrolene Suppliers

China 35 Germany 1 India 3 Italy 1 United Kingdom 2 United States 6 Global 48

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View Lastest Price from Dantrolene manufacturers

Career Henan Chemical Co

Product: Dantrolene 7261-97-4
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

7261-97-4, DantroleneRelated Search:

2-[1-(Aminocarbonyl)-2-[[5-(4-nitrophenyl)-2-furanyl]methylene]hydrazinyl]-acetic Acid Ethyl Ester aminodantrolene 2-Furaldehyde, semicarbazone 2-FURALDEHYDE DIMETHYLHYDRAZONE 5-HYDROXYDANTROLENE 1-Aminohydantoin hydrochloride Dantrolene

DANTRILENE

1-{(5-(4-NITROPHENYL)-2-FURANYL)METHYLENE}AMINO-2,4-IMIDAZOLIDENEDIONE

1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione

1-[5-(4-Nitrophenyl)-2-furylmethyleneamino]imidazolidine-2,4-dione

C06939

Dantrolene (200 mg)

HYDRATED 1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]-2, 4-IMIDAZOLIDINEDIONE SODIUM SALT

2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-

1-{[5-(4-nitrophenyl)-2-furyl]methylideneamino} imidazolidine-2,4-dione

1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione

Dantrolene (1163140)

muscle spasticity,F368,inhibit,Inhibitor,neuroleptic malignant syndrome,F-368,Huntington's disease,Dantrolene,calcium signaling,malignant hyperthermia,F 368,ryanodine receptor,glutathione reductase

7261-97-4