ChemicalBook > CAS DataBase List > phenyltoloxamine

phenyltoloxamine

Product Name
phenyltoloxamine
CAS No.
92-12-6
Chemical Name
phenyltoloxamine
Synonyms
C-5581H;Aids033081;Aids-033081;phenyltoloxamine;Antihistamine compound;phenyltoloxamine USP/EP/BP;Dimethyl{2-[2-benzylphenoxy]ethyl}amine;2-(2-Benzylphenoxy)-N,N-dimethylethanamine;N,N-Dimethyl-2-(2-benzylphenoxy)ethaneamine;N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamine
CBNumber
CB0890034
Molecular Formula
C17H21NO
Formula Weight
255.35
MOL File
92-12-6.mol
More
Less

phenyltoloxamine Property

Melting point:
<25 °C
Boiling point:
bp 141-144° (at <0.1 mm Hg)
Density 
1.022±0.06 g/cm3(Predicted)
pka
pKa 9.1 (Uncertain)
EPA Substance Registry System
Phenyltoloxamine (92-12-6)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

phenyltoloxamine Chemical Properties,Usage,Production

Originator

Bristalin, Bristol ,US,1952

Definition

ChEBI: Phenyltoloxamine is a diarylmethane.

Manufacturing Process

Sodium methylate is made by dropping 11.7 g of sodium strips into 199 ml of absolute methanol in a 1-liter three-necked flask. 93.9 g of o-benzylphenol are dissolved in 200 ml of dry toluene and added to the sodium methylate solution. The solution is distilled until the boiling point of toluene is reached. At the end of the distillation, enough toluene is added to restore the original volume of solvent.
109.5 g of dimethylaminoethyl chloride hydrochloride and 200 ml of toluene are placed in a 1-liter Erlenmeyer flask, cooled in an ice bath, and decomposed with 167.5 g of 20% sodium hydroxide solution. The toluene and water layers are separated, and the water layer is extracted again with 50 ml of toluene. The toluene layers are combined, washed with saturated salt solution, and dried over anhydrous potassium carbonate.
The dried dimethylaminoethyl chloride solution is poured into the toluene solution of the sodium salt of o-benzylphenol, heated to reflux, and refluxed 16 hours. After refluxing, enough water is added to the mixture to dissolve the precipitated solid. The layers are separated, and the toluene layer is further washed with water until the water extract is just slightly alkaline. The toluene solution is then made acid with 6N hydrochloric acid and extracted with water until no cloudiness is produced when the extract is made alkaline. The acidic aqueous extract is washed with ether, then made alkaline with 20% sodium hydroxide solution, and extracted into ether. The ether solution is washed several times with water, then with saturated salt solution, and is dried over anhydrous potassium carbonate. The dried solution is filtered and distilled. The product distills at 143.5°C/1 mm; 69.7 g of pale yellow oil are recovered.
57.1 g of the free base are dissolved in ether and precipitated with dry HCl. 66.0 g of crude hydrochloride are recovered. The hydrochloride is dissolved in 130 ml of reagent acetone by boiling, filtered hot, and allowed to cool. The crystalline material obtained on cooling is filtered, washed with a little acetone, washed with ether, and dried in vacuo. 44.8 g, MP 119.5°C to 121°C, are recovered from the first crop of crystals. Ethyl acetate may also be used as the solvent for recrystallization.

Therapeutic Function

Antihistaminic

phenyltoloxamine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

phenyltoloxamine Suppliers

Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22883
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
0755-66853366; 13670046396
Email
ORDERS@QCSRM.COM
Country
China
ProdList
24326
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
15229059051
Email
1027@dideu.com
Country
China
ProdList
9992
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
Xiamen Wonderful Bio Technology Co., Ltd.
Tel
+8613043004613
Email
Sara@xmwonderfulbio.com
Country
China
ProdList
283
Advantage
58
More
Less

View Lastest Price from phenyltoloxamine manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
phenyltoloxamine 92-12-6
Price
US $120.00/KG
Min. Order
1250KG
Purity
99%
Supply Ability
330T
Release date
2023-06-28
Dideu Industries Group Limited
Product
phenyltoloxamine 92-12-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

92-12-6, phenyltoloxamineRelated Search:


  • 2-(2-Benzylphenoxy)-N,N-dimethylethanamine
  • C-5581H
  • N,N-Dimethyl-2-(2-benzylphenoxy)ethaneamine
  • Aids033081
  • Aids-033081
  • phenyltoloxamine
  • N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamine
  • Antihistamine compound
  • Dimethyl{2-[2-benzylphenoxy]ethyl}amine
  • phenyltoloxamine USP/EP/BP
  • Ethanamine, N,N-dimethyl-2-[2-(phenylmethyl)phenoxy]-
  • 92-12-6