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Fungichromin

Product Name
Fungichromin
CAS No.
6834-98-6
Chemical Name
Fungichromin
Synonyms
Lagosin;Cogomycin;Fungichromin;Lagosin【antibiotic】;(3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one;Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-, (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-
CBNumber
CB0904201
Molecular Formula
C35H58O12
Formula Weight
670.83
MOL File
6834-98-6.mol
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Fungichromin Property

Melting point:
157-162° (dec)
alpha 
D20 -227.7° (c = 0.53 in DMF)
Boiling point:
914.0±65.0 °C(Predicted)
Density 
1.196±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
pka
12.77±0.70(Predicted)
color 
Light yellow to yellow
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Safety

Toxicity
LD50 in mice (mg/kg): 1624 orally; 33.3 i.p. (Umezawa, Tanaka)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20600
Product name
Lagosin
Purity
≥95%
Packaging
1mg
Price
$352
Updated
2024/03/01
Cayman Chemical
Product number
20600
Product name
Lagosin
Purity
≥95%
Packaging
5mg
Price
$1229
Updated
2024/03/01
ApexBio Technology
Product number
C3526
Product name
Lagosin
Packaging
5mg
Price
$1384
Updated
2021/12/16
ApexBio Technology
Product number
C3526
Product name
Lagosin
Packaging
1mg
Price
$395
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016850
Product name
FUNGICHROMIN
Purity
95.00%
Packaging
5MG
Price
$504.17
Updated
2021/12/16
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Fungichromin Chemical Properties,Usage,Production

Uses

Lagosin is a pentaene antifungal produced by Streptomyces, first isolated in 1958 by researchers at MIT in the USA. The discovery was soon followed by several independent isolations as lagosin and cogomyin. Initially these metabolites were thought to be isomeric, but Pandey and colleagues at NCI definitively demonstrated they were identical. Structurally, lagosin is 14-hydroxyfilipin III and the most polar member of the filipin family of fungicides. Lagosin exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols.

Definition

ChEBI: Fungichromin is a macrolide and an antibiotic antifungal drug.

Biological Activity

lagosin, a polyene macrolide antibiotic, has first been extracted from an isolate of a streptomyces species present in a sample of soil collected in lagos, nigeria [1]. it has been reported that the three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, showed some stereochemical differences at one or more centers [1].lagosin was the most polar member of the filipin family of fungicides with broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols. the antibiotic lagosin, which appeared to be identical to, or a stereoisomer of, fungichromin, and was very similar in structure to the filipins [2]. the equilibrium constants for association of the polyene antibiotics with aqueous suspensions of cholesterol follow the order filipin iil > amphotericin b > nystatin > lagosin, in agreement with the order reported for the extent of damage these antibiotics cause in natural and model membranes [2].

References

[1] pandey r c, guenther e c, aszalos a a, et al. physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin[j]. the journal of antibiotics, 1982, 35(8): 988-996.
[2] bittman r, fischkoff s a. fluorescence studies of the binding of the polyene antibiotics filipin iii, amphotericin b, nystatin, and lagosin to cholesterol[j]. proceedings of the national academy of sciences, 1972, 69(12): 3795-3799.

Fungichromin Preparation Products And Raw materials

Raw materials

Preparation Products

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Fungichromin Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
Country
China
ProdList
57423
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
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sales@mitachieve.com
Country
China
ProdList
8860
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Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Country
China
ProdList
3656
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58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ:2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4148
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
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Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
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Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
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1039@dideu.com
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China
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Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
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info@scrbio.com
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China
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10329
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Shanghai Yanchun Biopharmaceutical Technology Co., Ltd
Tel
4001-009266 17349750668
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product@sci-e.com
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China
ProdList
2808
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
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cindy.huang@synzest.com
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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+86-057181025280; +8617767106207
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0571-85806285
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sales@molcore.com
Country
China
ProdList
49734
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Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
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6834-98-6, FungichrominRelated Search:


  • Lagosin
  • Fungichromin
  • Cogomycin
  • Lagosin【antibiotic】
  • Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-, (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-
  • (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
  • 6834-98-6
  • C35H58O12