fenetylline hydrochloride Property

Melting point:

227-229°; mp 237-239°

solubility 

DMF: 0.3 mg/ml; DMSO: 0.5 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

Safety

Toxicity

LD50 oral in rat: 100mg/kg

DEA Controlled Substances

CSCN: 1503
CAS SCH: I
NARC: N

Hazard and Precautionary Statements (GHS)

fenetylline hydrochloride Chemical Properties,Usage,Production

Originator

Captagon,Homburg,W. Germany,1961

Uses

CNS stimulant. Controlled substance.

Manufacturing Process

1 mol of 7-(β-chloroethyl)-theophylline and 2? mols of α-methyl-β-phenyl ethylamine are heated for 6 hours in an oil bath, if necessary with addition of alcohol or toluene. The reaction mixture is diluted with alcohol and acidified with alcoholic hydrochloric acid. The crystalline mass formed is filtered with suction and extracted by boiling with alcohol. A product having a melting point of 237°C to 239°C is formed. With prolonged extraction by boiling with alcohol, the melting point of the mass falls, preferably due to a change in modification, to 227°C to 229°C. However, analysis shows that both products are the pure condensation product.
Instead of the chloroethyl theophylline, it is also possible to use the corresponding bromine derivative. It was found that in this way the process is facilitated and the yield is improved

Therapeutic Function

Central stimulant