ChemicalBook > CAS DataBase List > amiphenazole
amiphenazole
- Product Name
- amiphenazole
- CAS No.
- 490-55-1
- Chemical Name
- amiphenazole
- Synonyms
- Daftazol;Daptazile;Amifenazol;Phenamizol;Phenamizole;Amifenazole;Amiphenazol;amiphenazole;Amifenazol [inn-spanish];2,4-Diamino-5-phenylthiazole
- CBNumber
- CB0909615
- Molecular Formula
- C9H9N3S
- Formula Weight
- 191.25
- MOL File
- 490-55-1.mol
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amiphenazole Property
- Melting point:
- 163.5°C (rough estimate)
- Boiling point:
- 413.3±25.0 °C(Predicted)
- Density
- 1.1906 (rough estimate)
- refractive index
- 1.5300 (estimate)
- pka
- 5.12±0.10(Predicted)
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N-Bromosuccinimide Price
Crysdot
- Product number
- CD11117196
- Product name
- 5-Phenylthiazole-2,4-diamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11117196
- Product name
- 5-Phenylthiazole-2,4-diamine
- Purity
- 97%
- Packaging
- 5g
- Price
- $270
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11117196
- Product name
- 5-Phenylthiazole-2,4-diamine
- Purity
- 97%
- Packaging
- 10g
- Price
- $450
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11117196
- Product name
- 5-Phenylthiazole-2,4-diamine
- Purity
- 97%
- Packaging
- 25g
- Price
- $880
- Updated
- 2021/12/16
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amiphenazole Chemical Properties,Usage,Production
Originator
Aamphisol,RJR
Definition
ChEBI: Amiphenazole is a member of thiazoles.
Manufacturing Process
Thiourea reacted with α-bromophenylacetonitrile and as a result of this
reaction 2-(cyanophenylmethyl)isothiourea was obtained.
By cyclisation of the 2-(cyanophenylmethyl)isothiourea 2,4-diamino-5-
phenylthiazole (amiphenazol) was produced.
Therapeutic Function
Respiratory stimulant, Barbiturate antagonist, Morphine antagonist
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 4517, 1951 DOI: 10.1021/ja01154a005
Purification Methods
The thiazole crystallises from aqueous EtOH or water. Store it in the dark under N2. The hydrochloride has m 273-274o(dec) (from MeOH/EtOAc), and the picrate has m 189-191o(dec) (from H2O). [Davies et al. J Chem Soc 3491 1950, Dodson & Turner J Am Chem Soc 73 4517 1951, Beilstein 27 III/IV 5139.]
amiphenazole Preparation Products And Raw materials
Raw materials
Preparation Products
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490-55-1, amiphenazoleRelated Search:
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2-AMINO-5-METHYLTHIAZOLE
5-phenylthiazol-2-amine
2,4-DIAMINO-5-PHENYLTHIAZOLE MONOHYDROBROMIDE
amiphenazole
thiazol-4-amine