4,6-diamino-2-bromonicotinonitrile
- Product Name
- 4,6-diamino-2-bromonicotinonitrile
- CAS No.
- 42530-03-0
- Chemical Name
- 4,6-diamino-2-bromonicotinonitrile
- Synonyms
- 2-Bromo-3-cyano-4,6-diaminopyridine;2,4-diamino-5-cyano-6-bromopyridine;4,6-diamino-2-bromopyridine-3-carbonitrile;4,6-Diamino-2-bromo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 4,6-diamino-2-bromo-
- CBNumber
- CB0912477
- Molecular Formula
- C6H5BrN4
- Formula Weight
- 213.03
- MOL File
- 42530-03-0.mol
4,6-diamino-2-bromonicotinonitrile Property
- Boiling point:
- 503.5±50.0 °C(Predicted)
- Density
- 1.88±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.11±0.48(Predicted)
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D415078
- Product name
- 4,6-Diamino-2-bromonicotinonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3156AE
- Product name
- 4,6-Diamino-2-bromonicotinonitrile
- Packaging
- 5g
- Price
- $1009
- Updated
- 2021/12/16
- Product number
- 038526
- Product name
- 4,6-Diamino-2-bromonicotinonitrile
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- CM125338
- Product name
- 4,6-diamino-2-bromonicotinonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 61-11017
- Product name
- 4,6-Diamino-2-bromonicotinonitrile
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
4,6-diamino-2-bromonicotinonitrile Chemical Properties,Usage,Production
Synthesis
109-77-3
42530-03-0
The general procedure for the synthesis of 4,6-diamino-2-bromo-3-cyanopyridine from malononitrile was as follows: HBr gas was bubbled into a mixture of malononitrile (16.3 g, 0.247 mol) and toluene (400 mL) for 2 hr at 0 °C, and a pale yellow precipitate was formed during the reaction. Subsequently, the reaction mixture was heated to 100 °C and maintained for 2 h, during which a large amount of gas production was observed. Upon completion of the reaction, it was cooled to room temperature and the yellow solid product was separated by diafiltration and washed with toluene and subsequently dried in air. The resulting solid (25.96 g) was mixed with water (500 mL) and the pH of the suspension was adjusted to 9-10 with NH4OH (~15 mL, concentration ~15%). the mixture was stirred at room temperature for 1 hr and the mixture was filtered. The product was purified by recrystallization from EtOH to give a yellow solid. Finally, it was dried in a vacuum oven at 60 °C to obtain 4,6-diamino-2-bromo-3-cyanopyridine (12.95 g, 49% yield). The structure of the product was confirmed by 1H NMR (DMSO): δ 6.67 (2H, brs), 6.55 (2H, brs), 5.59 (1H, s).
References
[1] Patent: US5654307, 1997, A
[2] Liebigs Annalen der Chemie, 1980, # 6, p. 946 - 953
4,6-diamino-2-bromonicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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