ChemicalBook > CAS DataBase List > diethadione
diethadione
- Product Name
- diethadione
- CAS No.
- 702-54-5
- Chemical Name
- diethadione
- Synonyms
- Toce;L-1811;Dioxone;Ledosten;HSDB 5514;Diethadion;diethadione;Diethadionum;5,5-diethyl-1,3-oxazinane-2,4-dione;5,5-diethyl-1,3-oxazinane-2,4-quinone
- CBNumber
- CB0928351
- Molecular Formula
- C8H13NO3
- Formula Weight
- 171.19
- MOL File
- 702-54-5.mol
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diethadione Property
- Melting point:
- 97-98°
- Boiling point:
- 301.17°C (rough estimate)
- Density
- 1.1998 (rough estimate)
- refractive index
- 1.4750 (estimate)
- form
- Solid
- color
- Light yellow to yellow
- CAS DataBase Reference
- 702-54-5
- EPA Substance Registry System
- Diethadione (702-54-5)
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Safety
- Hazardous Substances Data
- 702-54-5(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): 52, 31.6 i.p.; 130, 70.5 orally (Maffii)
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- API0016533
- Product name
- 5,5-DIETHYL-1,3-OXAZINANE-2,4-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.34
- Updated
- 2021/12/16
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diethadione Chemical Properties,Usage,Production
Uses
Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active[1].
Definition
ChEBI: Diethadione is an oxazinane.
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and intramuscular routes. An analeptic (central nervous system stimulant). When heated to decomposition it emits toxic fumes of NOx
in vivo
Dioxone (0-30 mg/kg; i.v., i.p., oral, s.c.; once) induces convulsant action[1].
| Animal Model: | CF-1 Mice and CF-Wistar rats[1] |
| Dosage: | 0-30 mg/kg |
| Administration: | Intraperitoneal injection, once |
| Result: | In mice: The spontaneous activity was often reduced, always accompanied by hyperreactivity at 10 mg/kg, tremors, clonic convulsion and motor incoordination phenomena occured after the administration of 30 mg/kg. In rats: Tremors and some isolated clonus of the muscles of the limbs were observed with 10 mg/kg, clonic convukions occurred with doses above 15 mg/kg. |
References
[1] G MAFFII, et al. A new analeptic: 5, 5-diethyl-1, 3-oxazine-2,4-dione (Dioxone). J Pharm Pharmacol. 1961 Apr;13:244-53. DOI:10.1111/j.2042-7158.1961.tb11818.x
diethadione Preparation Products And Raw materials
Raw materials
Preparation Products
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