4-Bromo-6-cyanoquinoline
- Product Name
- 4-Bromo-6-cyanoquinoline
- CAS No.
- 642477-82-5
- Chemical Name
- 4-Bromo-6-cyanoquinoline
- Synonyms
- 4-Bromo-6-cyanoquinoline;4-Bromo-6-quinolinecarbonitrile;6-Quinolinecarbonitrile, 4-bromo-
- CBNumber
- CB0947552
- Molecular Formula
- C10H5BrN2
- Formula Weight
- 233.06
- MOL File
- 642477-82-5.mol
4-Bromo-6-cyanoquinoline Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 292759
- Product name
- 4-Bromoquinoline-6-carbonitrile
- Packaging
- 100.00mg
- Price
- $36
- Updated
- 2026/05/19
- Product number
- 292759
- Product name
- 4-Bromoquinoline-6-carbonitrile
- Packaging
- 250.00mg
- Price
- $72
- Updated
- 2026/05/19
- Product number
- 292759
- Product name
- 4-Bromoquinoline-6-carbonitrile
- Packaging
- 1.00g
- Price
- $210
- Updated
- 2026/05/19
- Product number
- B53382
- Product name
- 4-Bromoquinoline-6-carbonitrile
- Purity
- 97%
- Packaging
- 100mg
- Price
- $70
- Updated
- 2026/05/06
- Product number
- B53382
- Product name
- 4-Bromoquinoline-6-carbonitrile
- Purity
- 97%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2026/05/06
4-Bromo-6-cyanoquinoline Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 2232, 2007 DOI: 10.1021/jo062168u
Synthesis
642477-81-4
642477-82-5
General procedure for the synthesis of 4-bromo-6-cyanoquinoline from 4-oxo-1,4-dihydroquinoline-6-carbonitrile: Phosphorus tribromide (8 ml, 84.6 mmol) was added drop-wise to a solution of 4-oxo-1,4-dihydroquinoline-6-carbonitrile (12 g, 70.5 mmol) in N,N-dimethylformamide (DMF, 75 ml) over a period of 5 min, the reaction being The reaction is slightly exothermic. Upon completion of the reaction, the reaction mixture was cooled to room temperature and then diluted with ice water (100 ml) and stirring was continued for 1 hour. Subsequently, the reaction mixture was further diluted with additional water (300 ml). The solid product was collected by filtration, washed with water and dried in air to give 14.3 g of the target product in 87% yield. Mass spectrum (positive ion electrospray) m/z 233 (MH+).
References
[1] Patent: WO2004/2490, 2004, A2. Location in patent: Page/Page column 39
[2] Patent: WO2004/2992, 2004, A1. Location in patent: Page 95
[3] Patent: WO2007/16610, 2007, A2. Location in patent: Page/Page column 32
[4] Tetrahedron Letters, 2010, vol. 51, # 20, p. 2685 - 2689
4-Bromo-6-cyanoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-6-cyanoquinoline Suppliers
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