ChemicalBook > CAS DataBase List > 6-Methoxy-1H-indazole

6-Methoxy-1H-indazole

Product Name
6-Methoxy-1H-indazole
CAS No.
3522-07-4
Chemical Name
6-Methoxy-1H-indazole
Synonyms
6-methoxyindazole;6-Methoxy-1H-indazoL;6-Methyloxy-indazole;6-Methoxy-1H-indazole
CBNumber
CB0970673
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
3522-07-4.mol
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6-Methoxy-1H-indazole Property

Melting point:
97-99 °C
Boiling point:
312.5±15.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.29±0.40(Predicted)
Appearance
Off-white to yellow Solid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
J50206
Product name
6-Methoxy-1H-indazole
Packaging
5g
Price
$285
Updated
2021/12/16
SynQuest Laboratories
Product number
4H07-1-32
Product name
6-Methoxy-1H-indazole
Packaging
1g
Price
$345
Updated
2021/12/16
Matrix Scientific
Product number
068733
Product name
6-Methoxyindazole
Purity
>95%
Packaging
1g
Price
$415
Updated
2021/12/16
AK Scientific
Product number
L862
Product name
6-Methoxy-1H-indazole
Packaging
5g
Price
$735
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0097245
Product name
6-METHOXY-1H-INDAZOLE
Purity
95.00%
Packaging
1G
Price
$1492.26
Updated
2021/12/16
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6-Methoxy-1H-indazole Chemical Properties,Usage,Production

Uses

6-Methoxy-1H-indazole is used as a raw material for organic synthesis or as a pharmaceutical intermediate compound. It can be used to prepare other heterocyclic compounds such as 1H-Indazol-6-ol, 6-Methoxy-1H-indazol-5-amine and 6-Methoxy-5-nitro-1H-indazole.

Synthesis

331-64-6

3522-07-4

The general procedure for the synthesis of 6-methoxy-1H-indazole from 2-fluoro-4-methoxybenzaldehyde is as follows: Preparation of intermediate 42: 2-fluoro-4-methoxybenzaldehyde (1 g, 6.5 mmol) was mixed with hydrazine (7 mL) and heated to reflux for 4 hours. After completion of the reaction, the reaction mixture was extracted with dichloromethane (3 x 75 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 6-methoxy-1H-indazole (Intermediate 42) (568 mg, 59% yield) as a yellow solid. Product characterization: HPLC purity 99%, retention time 2.159 min; mass spectrum (ESI) m/z 149.1 [M+H]+.

References

[1] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8166 - 8172
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 8, p. 3076 - 3080
[3] Journal of Organic Chemistry, 2009, vol. 74, # 16, p. 6331 - 6334
[4] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 73
[5] Patent: CN108727267, 2018, A. Location in patent: Paragraph 0106; 0107; 0108

6-Methoxy-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Methoxy-1H-indazole manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
6-Methoxy-1H-indazole 3522-07-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-25
Shaanxi Dideu Medichem Co. Ltd
Product
6-Methoxy-1H-indazole 3522-07-4
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-12
Career Henan Chemical Co
Product
6-Methoxy-1H-indazole 3522-07-4
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

3522-07-4, 6-Methoxy-1H-indazoleRelated Search:

6-Methoxy-1H-indazole-3-carboxyaldehyde 1H-INDOLE-3-CARBONITRILE, 6-METHOXY- 6-METHOXYPYRIDINE-3-CARBOTHIOAMIDE 3-Iodo-5,6-dimethoxy-1H-indazole 3-IODO-6-METHOXY-1H-INDAZOLE METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE 5-Methoxy-1H-indazole-3-carboxylic acid ,97% 3-Cyano-5-methoxy-1H-indazole,5-METHOXY-1H-INDAZOLE-3-CARBONITRILE 5-Methoxy-1H-indazole ,97% 3-Cyano-6-methoxy-1H-indazole 6-METHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID 5-Methoxy-1H-indazole-3-carboxyaldehyde,5-METHOXY-1H-INDAZOLE-3-CARBALDEHYDE, 95+% 5,6-DIMETHOXY-1H-INDAZOLE 5,6-DIMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID 5,6-DIMETHOXY-1H-INDAZOLE-3-CARBONITRILE 6-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE METHYL 6-METHOXY-1H-INDAZOLE-3-CARBOXYLATE 6-BENZYLOXY-1H-INDAZOLE-3-CARBOXYLIC ACID

  • 6-Methoxy-1H-indazole
  • 6-methoxyindazole
  • 6-Methyloxy-indazole
  • 6-Methoxy-1H-indazoL
  • 3522-07-4
  • 5926-00-9
  • 3522/7/4