2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

Product Name: 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
CAS No.: 141286-78-4
Chemical Name: 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
Synonyms: PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors;2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
CBNumber: CB0972925
Molecular Formula: C16H16F2N2O4S2
Formula Weight: 402.44
MOL File: 141286-78-4.mol

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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Property

Boiling point:: 617.6±65.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: protect from light
solubility: DMSO: >20mg/mL
form: solid
pka: 10.44±0.40(Predicted)
color: white
InChIKey: GTACSIONMHMRPD-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D8941
Product name: 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $178
Updated: 2024/03/01

Sigma-Aldrich

Product number: D8941
Product name: 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $728
Updated: 2024/03/01

Cayman Chemical

Product number: 29190
Product name: PEPA
Packaging: 5mg
Price: $88
Updated: 2024/03/01

Cayman Chemical

Product number: 29190
Product name: PEPA
Packaging: 10mg
Price: $121
Updated: 2024/03/01

TRC

Product number: P999023
Product name: PEPA
Packaging: 25mg
Price: $190
Updated: 2021/12/16

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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Chemical Properties,Usage,Production

Uses

PEPA is an allosteric potentiator of AMPA desensitization.

Biological Activity

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Biochem/physiol Actions

2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Suppliers

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141286-78-4, 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)ERelated Search:

Dimethyl sulfoxide 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E 3-Aminopyridine

2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide

2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)

PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors

Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-

141286-78-4

C16H16N2O4S2F2