TCS 359
- Product Name
- TCS 359
- CAS No.
- 301305-73-7
- Chemical Name
- TCS 359
- Synonyms
- TCS359;CS-1153;TCS359; TCS-359;Flt-3 inhibitor;TCS 359 USP/EP/BP;Flt-3 Inhibitor TCS359 TCS-359;2-(3,4-DIMETHOXY-BENZOYLAMINO)-4,5,6,7-T;Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem;2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide;2-(3,4-diMethoxybenzaMido)- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxaMide
- CBNumber
- CB0973098
- Molecular Formula
- C18H20N2O4S
- Formula Weight
- 360.43
- MOL File
- 301305-73-7.mol
TCS 359 Property
- Boiling point:
- 454.4±45.0 °C(Predicted)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- H2O: <2mg/mL
- pka
- 12.43±0.20(Predicted)
- form
- White solid
- color
- white to off-white
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 301305-73-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D5943
- Product name
- 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- 343020
- Product name
- Flt-3 Inhibitor
- Packaging
- 5mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- D5275
- Product name
- TCS 359
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $175
- Updated
- 2024/03/01
- Product number
- D5275
- Product name
- TCS 359
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $478
- Updated
- 2024/03/01
- Product number
- J64484
- Product name
- Flt-3 Inhibitor
- Packaging
- 10mg
- Price
- $275
- Updated
- 2023/06/20
TCS 359 Chemical Properties,Usage,Production
Uses
Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer. FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 μM). It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.
Uses
TCS 359 is a potent inhibitor of FLT3 used in the treatment of leukemia.
Definition
ChEBI: 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide is a dimethoxybenzene.
Biological Activity
Potent inhibitor of FLT3 receptor tyrosine kinase (IC 50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukaemia cell line expressing a constitutively active mutant FLT3 (IC 50 = 340 nM).
storage
Store at +4°C
References
[1]. trzci′nska-daneluti a.m., nguyen l., jiang c., et al. use of kinase inhibitors to correct δf508-cftr function. molecular & cellular proteomics, 2012, 11(9):745-757.
[2]. patch r.j., baumann c.a., liu j., et al. identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of flt3. bioorganic & medicinal chemistry letters, 2006, 16: 3282-3286.
[3]. kar r.k., suryadevara p., roushan r., et al. quantifying the structural requirements for designing newer flt3 inhibitors. medicinal chemistry, 2012, 8:913-927.
[4]. nishijima c., kawamura k., okamoto n., et al. regulation of preimplantation embryo development in mice by fms-like tyrosine kinase 3 ligand. journal of mammalian ova research, 2014, 31(1):45-51.
[5]. o'farrell a.m., yuen h.a., smolich b., et al. effects of su5416, a small molecule tyrosine kinase receptor inhibitor, on flt3 expression and phosphorylation in patients with refractory acute myeloid leukemia. leuk. res., 2004, 28(7):679-89.
TCS 359 Preparation Products And Raw materials
Raw materials
Preparation Products
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