ChemicalBook > CAS DataBase List > 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT

1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT

Product Name
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
CAS No.
168021-79-2
Chemical Name
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
Synonyms
CPI22;D03875;HPN-07;CS-791;CPI 22;CPI-22;CXY059;OKN007;CXY 059;CXY-059
CBNumber
CB11009515
Molecular Formula
C11H14NNa2O7S2
Formula Weight
382.3409
MOL File
168021-79-2.mol
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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Property

Melting point:
>300 °C
storage temp. 
-20°C
solubility 
Soluble in DMSO
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2163
Product name
HPN-07
Purity
≥98% (HPLC)
Packaging
5mg
Price
$64.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2163
Product name
HPN-07
Purity
≥98% (HPLC)
Packaging
25mg
Price
$264
Updated
2024/03/01
Cayman Chemical
Product number
22109
Product name
NXY-059
Purity
≥98%
Packaging
5mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
22109
Product name
NXY-059
Purity
≥98%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
22109
Product name
NXY-059
Purity
≥98%
Packaging
25mg
Price
$176
Updated
2024/03/01
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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Chemical Properties,Usage,Production

Uses

A free radical trapping compound

Uses

Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Used as a spin-trap agent. It is a clinically tested antioxidant and depicts potency against Ischemic stress, Neuroprotection.

Biological Activity

Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.

Biochem/physiol Actions

Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).

References

[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesjö bk.

1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Suppliers

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168021-79-2, 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALTRelated Search:


  • 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
  • disufenton sodium
  • Cerovive
  • D03875
  • Disufenton sodium (usan/inn)
  • NXY-059(Disufentonsodium)
  • Disufenton sodium (NXY-059)
  • 4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonicaciddisodiumsalt
  • Cerovive(NXY-059)
  • NXY-059(Cerovive)
  • Disufenton sodiuM (NXY 059,Cerovive)
  • NXY059/NXY-059
  • Disufenton
  • 1,3-Benzenedisulfonic acid, 4-[[(1,1-dimethylethyl)imino]methyl]-, N-oxide, disodium salt
  • Disodium,4-[(Z)-[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate
  • HPN-07
  • NXY 059 (CEROVIVE);NXY059
  • CS-791
  • ARL-16556
  • CPI 22
  • CPI22
  • CPI-22
  • CXY 059
  • CXY059
  • CXY-059
  • NXY059; NXY 059; NXY-059; CXY 059; CXY059; CXY-059; OKN007; OKN-007; OKN 007; ARL 16556; ARL16556; ARL-16556; CPI-22; CPI22; CPI 22; CEROVIVE; DISUFENTON SODIUM
  • OKN 007
  • OKN007
  • OKN-007
  • ARL 16556
  • ARL16556
  • Disufenton sodium Cerovive NXY-059
  • Disufenton sodium,Inhibitor,Reactive Oxygen Species,inhibit,Disufenton
  • 168021-79-2
  • C11H13NNa2O7S2
  • C11H14NNa2O7S2
  • Inhibitors