4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE

Product Name: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE
CAS No.: 263149-10-6
Chemical Name: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE
Synonyms: Bosutinib Impurity 35;4-Chloro-3-cyano-7-hydroxy-6-methoxyquinoline;4-Chloro-7-hydroxy-6-methoxyquinoline-3-carbo...;4-chloro-6-methoxy-7-oxo-1H-quinoline-3-carbonitrile;4-Chloro-7-hydroxy-6-methoxy-3-quinolinecarbonitrile;4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE;3-Quinolinecarbonitrile, 4-chloro-7-hydroxy-6-Methoxy-;4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE ISO 9001：2015 REACH
CBNumber: CB11010621
Molecular Formula: C11H7ClN2O2
Formula Weight: 234.64
MOL File: Mol file

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4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Property

Melting point:: >72°C (dec.)
Boiling point:: 439.0±40.0 °C(Predicted)
Density: 1.48
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 7.41±0.40(Predicted)
form: Solid
color: Pale Yellow
InChI: InChI=1S/C11H7ClN2O2/c1-16-10-2-7-8(3-9(10)15)14-5-6(4-13)11(7)12/h2-3,5,15H,1H3
InChIKey: QIORUBTUDLGIII-UHFFFAOYSA-N
SMILES: N1C2C(=CC(OC)=C(O)C=2)C(Cl)=C(C#N)C=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368585
Product name: 4-Chloro-7-hydroxy-6-methoxy-3-quinolinecarbonitrile
Packaging: 500mg
Price: $180
Updated: 2021/12/16

TRC

Product number: C368585
Product name: 4-Chloro-7-hydroxy-6-methoxy-3-quinolinecarbonitrile
Packaging: 1g
Price: $275
Updated: 2021/12/16

AK Scientific

Product number: 2319AB
Product name: 4-Chloro-7-hydroxy-6-methoxyquinoline-3-carbonitrile
Packaging: 1g
Price: $211
Updated: 2021/12/16

ChemScene

Product number: CS-B0215
Product name: 3-Quinolinecarbonitrile,4-chloro-7-hydroxy-6-methoxy-
Purity: >97.0%
Packaging: 1g
Price: $87
Updated: 2021/12/16

AK Scientific

Product number: 2319AB
Product name: 4-Chloro-7-hydroxy-6-methoxyquinoline-3-carbonitrile
Packaging: 250mg
Price: $117
Updated: 2021/12/16

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4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Chemical Properties,Usage,Production

Uses

4-Chloro-7-hydroxy-6-methoxy-3-quinolinecarbonitrile is a synthetic compound used in the synthesis of Src inhibitors.

Synthesis

214476-99-0

263149-10-6

The general procedure for the synthesis of 4-chloro-7-hydroxy-6-methoxy-3-carbonitrile quinoline from the compound (CAS:214476-99-0) is as follows: dissolve the raw material (19.23 g, 60.0 mmol) in trifluoroacetic acid (300 mL), add fennel sulfide (35 mL), and the reaction was carried out under nitrogen protection at reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and the trifluoroacetic acid was removed by rotary evaporator. The oily residue obtained was stirred with ice water and the pH was adjusted to alkaline with concentrated ammonia (specific gravity 0.880). The resulting suspension was filtered and the solid was washed sequentially with water, ethyl acetate and ether and dried to give 13.74 g of khaki colored solid product in 97% yield. Mass spectral analysis showed m/e 235 ([M+H]+).

References

[1] Patent: EP1584619, 2005, A1. Location in patent: Page/Page column 41-42
[2] Patent: US6297258, 2001, B1
[3] Patent: US6288082, 2001, B1
[4] Patent: EP1950201, 2008, A1. Location in patent: Page/Page column 64
[5] Patent: EP1117659, 2003, B1. Location in patent: Page 56

4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Suppliers

China 83 India 2 United States 6 Global 91

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View Lastest Price from 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE manufacturers

Career Henan Chemical Co

Product: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE 263149-10-6
Price: US $150.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-30

263149-10-6, 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILERelated Search:

Bosutinib Impurity 3 Bosutinib Impurity 4 Bosutinib Impurity 6 Bosutinib Impurity 15 Bosutinib Impurity 5-Amino-2,4-dichloroanisole 2-aMino-4-(3-chloropropoxy)-5-Methoxybenzoate 4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Bosutinib Monohydrate 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE 4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE

4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE

4-Chloro-3-cyano-7-hydroxy-6-methoxyquinoline

4-Chloro-7-hydroxy-6-methoxy-3-quinolinecarbonitrile

3-Quinolinecarbonitrile, 4-chloro-7-hydroxy-6-Methoxy-

4-Chloro-7-hydroxy-6-methoxyquinoline-3-carbo...

Bosutinib Impurity 35

4-chloro-6-methoxy-7-oxo-1H-quinoline-3-carbonitrile

4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE ISO 9001：2015 REACH

263149-10-6

263149-10-8