ChemicalBook > CAS DataBase List > 4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Product Name: 4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 50920-64-4
Chemical Name: 4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate;Ethyl 1-ethyl-3-methylpyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 1-ethyl-3-methyl-, ethyl ester
CBNumber: CB11013147
Molecular Formula: C9H14N2O2
Formula Weight: 182.22
MOL File: 50920-64-4.mol

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4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Property

storage temp.: Sealed in dry,Room Temperature
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: Y5456
Product name: Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
Packaging: 5g
Price: $531
Updated: 2021/12/16

AK Scientific

Product number: Y5456
Product name: Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
Packaging: 10g
Price: $798
Updated: 2021/12/16

Crysdot

Product number: CD11113821
Product name: Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
Purity: 95+%
Packaging: 10g
Price: $554
Updated: 2021/12/16

Ambeed

Product number: A219504
Product name: Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
Purity: 95%
Packaging: 250mg
Price: $52
Updated: 2021/12/16

Ambeed

Product number: A219504
Product name: Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
Purity: 95%
Packaging: 1g
Price: $118
Updated: 2021/12/16

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4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

50920-65-5

64-17-5

50920-64-4

Oxalyl chloride (5.68 mL, 64.9 mmol) was slowly added dropwise to a suspension of 1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid (5 g, 32.4 mmol) dissolved in dichloromethane (40 mL) at room temperature and two drops of N,N-dimethylformamide (DMF) were added as catalyst. The reaction mixture was stirred at room temperature for 2 h, subsequently concentrated by rotary evaporator and dried under vacuum. Anhydrous ethanol (50 mL, 856 mmol) was added to the resulting residue and the reaction mixture continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was again concentrated by rotary evaporator and dried under vacuum. The light yellow oil obtained was dissolved in ethyl acetate (100 mL), washed sequentially with saturated sodium bicarbonate solution and brine, and the organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated. Finally, the residue was dried under vacuum to give ethyl 3-methyl-1-ethyl-1H-pyrazole-5-carboxylate (5.5 g, 30.2 mmol, 93% yield) as a light yellow oil. The product was characterized by 1H NMR (400 MHz, chloroform-d) and LCMS (LCMS method E): 1H NMR δ 6.63 (s, 1H), 4.56 (q, J = 7.11 Hz, 2H), 4.35 (q, J = 7.11 Hz, 2H), 2.30 (s, 3H), 1.44 (t, J = 7.28 Hz, 3H), 1.39 (t, J = 7.28 Hz, 3H); LCMS Rt = 0.81 min, [M + H]+ = 183.1.

References

[1] Patent: WO2017/175147, 2017, A1. Location in patent: Page/Page column 191

4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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50920-64-4, 4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTERRelated Search:

Ethyl 1-ethyl-3-methylpyrazole-5-carboxylate

Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate

1H-Pyrazole-5-carboxylic acid, 1-ethyl-3-methyl-, ethyl ester

50920-64-4