ChemicalBook > CAS DataBase List > 5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE

5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE

Product Name
5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE
CAS No.
4943-67-3
Chemical Name
5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE
Synonyms
5-METHYL-4-AZAINDOLE;5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE;1H-Pyrrolo[3,2-b]pyridine, 5-Methyl-
CBNumber
CB11013349
Molecular Formula
C8H8N2
Formula Weight
132.16
MOL File
4943-67-3.mol
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5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE Property

Boiling point:
268.7±20.0 °C(Predicted)
Density 
1.186±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.83±0.40(Predicted)
Appearance
Light yellow to green yellow Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M336743
Product name
5-Methyl-1H-pyrrolo[3,2-b]pyridine
Packaging
2mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
6692AB
Product name
5-Methyl-1H-pyrrolo[3,2-b]pyridine
Packaging
1g
Price
$632
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078832
Product name
5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078832
Product name
5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE
Purity
95.00%
Packaging
10G
Price
$1334.03
Updated
2021/12/16
Ambeed
Product number
A204334
Product name
5-Methyl-1H-pyrrolo[3,2-b]pyridine
Purity
95%
Packaging
100mg
Price
$101
Updated
2021/12/16
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5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE Chemical Properties,Usage,Production

Uses

5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE is an indole derivative used in pharmaceutical synthesis and organic experiments.

Synthesis

65156-94-7

823-96-1

4943-67-3

General procedure for the preparation of 5-methyl-1H-pyrrolo[3,2-b]pyridine: In a microwave reactor, 5-chloro-1H-pyrrolo[3,2-b]pyridine (200 mg, 1.31 mmol), trimethylcyclotriboroxane (0.20 mL, 1.44 mmol) and potassium carbonate (540 mg, 3.93 mmol) were suspended in 5 mL of 1,2-dimethoxyethane. methoxyethane. The mixture was degassed by three vacuum-argon cycles. Subsequently, [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride complex with dichloromethane (53 mg, 0.07 mmol) was added and again degassed by three vacuum-argon cycles. The reaction mixture was stirred at 120°C for 1 h under microwave radiation. After completion of the reaction, it was cooled to room temperature, diluted with ethyl acetate and water, filtered through Celite and eluted with more ethyl acetate and water. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue using an Isolera purification system (methanol-dichloromethane gradient, 0:100 ascending to 5:95) afforded 5-methyl-1H-pyrrolo[3,2-b]pyridine (95 mg, 0.72 mmol, 55% yield) as an oil with 96% purity. The product was confirmed by 1H NMR (300 MHz, chloroform-d): δ 8.44 (br.s, 1H), 7.60 (d, J = 8.24 Hz, 1H), 7.41 (t, J = 3.02 Hz, 1H), 7.01 (d, J = 8.24 Hz, 1H), 6.69 (br.s, 1H), 2.67 (s, 3H).UPLC/ MS (3 min) analysis showed a retention time of 0.45 min, LRMS: m/z 133 (M + 1).

References

[1] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 83-84
[2] Patent: EP2548876, 2013, A1. Location in patent: Paragraph 0287-0290

5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE Suppliers

China 42 India 1 United States 1 Global 44
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
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China
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42934
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Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3763
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58
Shanghai Devinchem Ltd
Tel
027-65318838 13646286950
Email
sales@devinchem.com
Country
China
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2953
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58
Jiaxing Novartis Chemical Co., Ltd.
Tel
18957373295
Fax
-
Country
China
ProdList
1580
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Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
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xingui2022@126.com
Country
China
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9979
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ShangHai AmK Pharmaceutical Technology Co., Ltd.
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微信 17321281695 18019252918
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17321281695
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sale@amkchem.com
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China
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15136
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Shenzhen Gre-syn Chemical Technology Co., Ltd.
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0755-0755-89366401 18617066401
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hangbingfang@163.com
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China
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951
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SuZhou ShiYa Biopharmaceuticals, Inc.
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0512-0512-52358471 17715136450
Fax
05125235 6881
Email
sales@shiyabiopharm.com
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China
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12127
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
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7181
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View Lastest Price from 5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE 4943-67-3
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-14
Career Henan Chemical Co
Product
5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE 4943-67-3
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

4943-67-3, 5-METHYL-1H-PYRROLO[3,2-B]PYRIDINERelated Search:

Indole 3-BROMO-5-METHYL-4-AZAINDOLE 5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE METHYL 5-(TRIFLUOROMETHYL)-1-TOSYL-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE 1H-Pyrrolo[3,2-b]pyridine-5-methanamine(9CI) 7-Chloro-2-ethyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile 3-IODO-5-METHYL-4-AZAINDOLE METHYL 5-(THIOPHEN-2-YL)-7-(TRIFLUOROMETHYL)-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLATE (1H-PYRROLO[3,2-B]PYRIDIN-5-YL)METHANAMINE DIHYDROCHLORIDE 1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile(9CI) 1,5-DIMETHYL-3-(2,4,6-TRIMETHYL-PHENYL)-1H-PYRROLO[3,2-B]PYRIDIN-7-YLAMINE METHYL 5-(TRIFLUOROMETHYL)-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE METHYL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLATE 3-(4-CHLORO-2-METHOXYPHENYL)-1,5-DIMETHYL-1H-PYRROLO[3,2-B]PYRIDIN-7-OL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLIC ACID

  • 5-METHYL-1H-PYRROLO[3,2-B]PYRIDINE
  • 5-METHYL-4-AZAINDOLE
  • 1H-Pyrrolo[3,2-b]pyridine, 5-Methyl-
  • 4943-67-3
  • Heterocycles series