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2-Methyl-[1,4] Benzoxazin-3(4H)-one

Product Name
2-Methyl-[1,4] Benzoxazin-3(4H)-one
CAS No.
21744-83-2
Chemical Name
2-Methyl-[1,4] Benzoxazin-3(4H)-one
Synonyms
2-Methyl-1,4-benzoxazin-3-one;2-methyl-4H-1,4-benzoxazin-3-one;2-Methyl-4H-benzo[1,4]oxazin-3-one;2-Methyl-[1,4] Benzoxazin-3(4H)-one;2H-1,4-Benzoxazin-3(4H)-one, 2-Methyl-;2-Methyl-2H-1,4-benzoxazin-3(4H)-one,97%;JRH-09901, 2-Methyl-2H-benzo[b][1,4]oxazin-3(4H)-one, 97%;2-Methyl-2H-benzo[b][1,4]oxazin-3(4H)-one
CBNumber
CB11033567
Molecular Formula
C9H9NO2
Formula Weight
163.17
MOL File
21744-83-2.mol
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2-Methyl-[1,4] Benzoxazin-3(4H)-one Property

Melting point:
143-144 °C
Boiling point:
330.6±31.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
12.92±0.40(Predicted)
color 
dark brown
CAS DataBase Reference
21744-83-2
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Safety

HS Code 
2914390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
JRD0784
Product name
2-Methyl-2<I>H</I>-benzo[<I>b</I>][1,4]oxazin-3(4<I>H</I>)-one
Packaging
1 g
Price
$185
Updated
2025/07/31
TRC
Product number
M320965
Product name
2-Methyl-4H-1,4-benzoxazin-3-one
Packaging
500mg
Price
$110
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-QR
Product name
2-Methyl-2H-1,4-benzoxazin-3(4H)-one
Packaging
1g
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
088240
Product name
2-Methyl-2H-1,4-benzoxazin-3(4H)-one
Packaging
1g
Price
$143
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0001806
Product name
2-METHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
Purity
95.00%
Packaging
100MG
Price
$434
Updated
2021/12/16
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2-Methyl-[1,4] Benzoxazin-3(4H)-one Chemical Properties,Usage,Production

Synthesis

95-55-6

535-11-5

21744-83-2

1. 125 mM potassium carbonate was added to 100 mL of anhydrous N,N-dimethylformamide (DMF). 2. 50 mM 2-amino-5-nitrophenol was added and stirred at room temperature for 1 hr until completely dissolved. 3. 50 mM 2-bromopropionic acid ethyl ester was added dropwise to the DMF solution in an ice bath under cooled conditions. 4. After the dropwise addition was completed, the reaction mixture was slowly warmed up to room temperature, and then reacted for 12 hrs at 90°C. 5. After the reaction was completed, the reaction mixture was cooled and some of the solvent was removed by distillation under reduced pressure. 6. 300-500 mL of ice water was added to the residue slowly and stirred until a solid precipitate was precipitated. After the reaction was completed, the reaction mixture was cooled and the solvent was removed by distillation under reduced pressure. 6. 300-500 mL of ice water was slowly added to the residue and stirred until a solid precipitate precipitated, and the stirring was continued for half an hour in an ice bath. 7. The precipitate was collected by filtration, and the filter cake was dried in vacuum to give 6.28 g of the intermediate in the form of a brown powder in 77.03% yield. 8. The intermediate was used directly in the subsequent reaction without further purification. 9. The intermediate was used directly in the subsequent reaction without further purification.

References

[1] Tetrahedron Letters, 2010, vol. 51, # 14, p. 1852 - 1855
[2] Chemistry - A European Journal, 2011, vol. 17, # 6, p. 1884 - 1893
[3] Tetrahedron, 2005, vol. 61, # 28, p. 6879 - 6885
[4] Patent: CN107459494, 2017, A. Location in patent: Paragraph 0279; 0281-0283

2-Methyl-[1,4] Benzoxazin-3(4H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-[1,4] Benzoxazin-3(4H)-one Suppliers

China 46 India 4 United Kingdom 1 United States 8 Global 59
Aladdin Scientific
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United States
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Synthonix Inc
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Heterocyclics Inc
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SynQuest Laboratories, Inc.
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Matrix Scientific
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Ryan Scientific, Inc.
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American Custom Chemicals Corporation
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3B Scientific Corporation
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View Lastest Price from 2-Methyl-[1,4] Benzoxazin-3(4H)-one manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Methyl-2H-1,4-Benzoxazin-3(4H)-One 21744-83-2
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19

21744-83-2, 2-Methyl-[1,4] Benzoxazin-3(4H)-oneRelated Search:

Thianaphthene bisoxatin 3 4-DIHYDRO-3-OXO-2H-(1 4)-BENZOXAZIN-2& METHYL 7-CHLORO-2-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 6-CHLORO-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 3-(2,6-DIMETHYL-3-OXO-2,3-DIHYDRO-BENZO[1,4]-OXAZIN-4-YL)-PROPIONIC ACID (E)-7-(1-Oxo-3-phenyl-2-propenyl)-2,2,4-trimethyl-2H-1,4-benzoxazin-3( 4H)-one 3-(2-METHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL)PROPANOIC ACID BISOXATIN ACETATE Diproxadol 2,4-dimethyl-7-(2-methylene-1-oxobutyl)-2H-1,4-benzoxazin-3(4H)-one 6-AMINO-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE 2,6-Dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

  • 2-Methyl-[1,4] Benzoxazin-3(4H)-one
  • 2H-1,4-Benzoxazin-3(4H)-one, 2-Methyl-
  • 2-Methyl-1,4-benzoxazin-3-one
  • 2-methyl-4H-1,4-benzoxazin-3-one
  • 2-Methyl-4H-benzo[1,4]oxazin-3-one
  • JRH-09901, 2-Methyl-2H-benzo[b][1,4]oxazin-3(4H)-one, 97%
  • 2-Methyl-2H-1,4-benzoxazin-3(4H)-one,97%
  • 2-Methyl-2<i>H</i>-benzo[<i>b</i>][1,4]oxazin-3(4<i>H</i>)-one
  • 21744-83-2