5-IODO-1H-PYRIMIDIN-4-ONE

Product Name: 5-IODO-1H-PYRIMIDIN-4-ONE
CAS No.: 4349-07-9
Chemical Name: 5-IODO-1H-PYRIMIDIN-4-ONE
Synonyms: 108307;5-Iodopyrimidin-4-ol;5-Iodo-4-pyrimidinol;5-Iodopyrimidine-4-ol;5-Iodo-4(3H)-pyrimidinone;5-iodopyriMidin-4(1H)-one;5-IODO-1H-PYRIMIDIN-4-ONE;5-iodo-1h-pyrimidin-6-one;4-Hydroxy-5-iodopyriMidine;4(3H)-Pyrimidinone, 5-iodo-
CBNumber: CB1103375
Molecular Formula: C4H3IN2O
Formula Weight: 221.98
MOL File: 4349-07-9.mol

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5-IODO-1H-PYRIMIDIN-4-ONE Property

Melting point:: 254-265℃
Density: 2.40±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 7.48±0.40(Predicted)
form: Solid
Appearance: Light yellow to brown Solid
Water Solubility: Soluble in water (67 g/L) (25°C).
Sensitive: Light Sensitive
CAS DataBase Reference: 4349-07-9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: I737108
Product name: 5-Iodopyrimidin-4-ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 073263
Product name: 5-Iodopyrimidin-4-ol
Purity: 95+%
Packaging: 1g
Price: $215
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0318364
Product name: 5-IODOPYRIMIDIN-4-OL
Purity: 95.00%
Packaging: 5MG
Price: $499.85
Updated: 2021/12/16

AK Scientific

Product number: W6277
Product name: 5-Iodopyrimidin-4-ol
Packaging: 5g
Price: $590
Updated: 2021/12/16

Matrix Scientific

Product number: 073263
Product name: 5-Iodopyrimidin-4-ol
Purity: 95+%
Packaging: 5g
Price: $765
Updated: 2021/12/16

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5-IODO-1H-PYRIMIDIN-4-ONE Chemical Properties,Usage,Production

Uses

4-Hydroxy-5-iodopyrimidine is an intermediate used in pharmaceuticals and chemical research.

Synthesis

51953-18-5

4349-07-9

General procedure for the synthesis of 4-hydroxy-5-iodopyrimidines from 4-hydroxypyrimidines: 10 g of 4(3H)-pyrimidinone was dissolved in 156 mL of acetic acid, and 25.8 g of N-iodosuccinimide was slowly added at 70 °C. The reaction system was then warmed up to 100 °C and the reaction was continuously stirred for 30 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature and then placed in an ice bath to promote crystallization of the product. Upon completion of crystallization, filtration was carried out under reduced pressure. The resulting solid was washed several times with deionized water and finally dried under reduced pressure to afford the target product 4-hydroxy-5-iodopyrimidine (16 g, yield: 67%). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 12.88 (broad peak, 1H), 8.42 (single peak, 1H), 8.17 (single peak, 1H).

References

[1] Synthesis (Germany), 2012, vol. 44, # 22, p. 3496 - 3504
[2] Patent: WO2011/99764, 2011, A2. Location in patent: Page/Page column 43
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 9, p. 2419 - 2422
[4] Patent: WO2005/16914, 2005, A1. Location in patent: Page/Page column 45
[5] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 7, p. 2719 - 2724

5-IODO-1H-PYRIMIDIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-IODO-1H-PYRIMIDIN-4-ONE Suppliers

China 72 India 4 United States 6 Global 82

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4349-07-9, 5-IODO-1H-PYRIMIDIN-4-ONERelated Search:

8-FLUORO-4-HYDROXYQUINOLINE 3-Bromo-4-hydroxy-5-nitropyridine 3,5-Diiodo-4-hydroxypyridine 4-Hydroxy-6-methoxyquinoline-3-carbonitrile 4-HYDROXY-5-BROMOQUINOLINE 4-Hydroxy-3-methyl-1H-indazole 4-HYDROXY-7-NITROQUINOLINE 1-Methylazepan-4-ol Benzaldehyde, 4-hydroxy-2-iodo- 3-iodopyridin-4-ol 5-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 2-Pyridinecarboxylic acid, 4-hydroxy-, methyl ester (9CI) 4-Hydroxy-2-pyridinecarboxylic acid ethyl ester 4-IODO-PYRIDIN-3-OL 2, 4-DICHLORO-5-IODOPYRIMIDINE 5-IODO-1H-PYRIMIDIN-4-ONE 2-AMINO-5-IODO-6-PHENYL-4(1H)-PYRIMIDINONE 6-(1-FLUOROETHYL)-5-IODO-4(1H)-PYRIMIDINONE

5-IODO-1H-PYRIMIDIN-4-ONE

5-Iodopyrimidin-4-ol

5-iodopyriMidin-4(1H)-one

5-Iodo-4(3H)-pyrimidinone

5-Iodo-4-pyrimidinol

4-Hydroxy-5-iodopyriMidine

5-iodo-1h-pyrimidin-6-one

108307

5-iodo-3,4-dihydropyrimidin-4-one

4(3H)-Pyrimidinone, 5-iodo-

5-Iodopyrimidine-4-ol

4349-07-9