IL-1R Antagonist
- Product Name
- IL-1R Antagonist
- CAS No.
- 566914-00-9
- Chemical Name
- IL-1R Antagonist
- Synonyms
- IL-1R Antagonist;TLR1, 10 mM in DMSO;IL-1R antagonist(TLR1);I912552 IL-1R Antagonist,98%;TLR1,TLR-1,TLR 1,Inhibitor,MyD88,inhibit;Benzenepropanamide, N-[(1S)-2-methyl-1-(pyrrolidinylcarbonyl)propyl]-;Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-;N-[(2S)-3-Methyl-1-oxo-1-(1-pyrrolidinyl)-2-butanyl]-3-phenylpropanamide;(S)-N-(3-Methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-3-phenylpropanamide
- CBNumber
- CB11038456
- Molecular Formula
- C18H26N2O2
- Formula Weight
- 302.41
- MOL File
- 566914-00-9.mol
IL-1R Antagonist Property
- storage temp.
- 2-8°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21349
- Product name
- IL-1R Antagonist
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 21349
- Product name
- IL-1R Antagonist
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 21349
- Product name
- IL-1R Antagonist
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- BA163771
- Product name
- IL-1R Antagonist
- Packaging
- 1mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 7647CR
- Product name
- IL-1RAntagonist
- Packaging
- 5mg
- Price
- $191
- Updated
- 2021/12/16
IL-1R Antagonist Chemical Properties,Usage,Production
Uses
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].
Biological Activity
Cell permeable: yes', 'Primary Target
TIR domain-mediated MyD88/IL1-RI interaction', 'Product does not compete with ATP.', 'Reversible: no
in vivo
TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.)[1].
References
[1] Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6. DOI:10.1073/pnas.0932746100
IL-1R Antagonist Preparation Products And Raw materials
Raw materials
Preparation Products
IL-1R Antagonist Suppliers
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