Benzamide, 2-amino-4-fluoro- (9CI)
- Product Name
- Benzamide, 2-amino-4-fluoro- (9CI)
- CAS No.
- 119023-25-5
- Chemical Name
- Benzamide, 2-amino-4-fluoro- (9CI)
- Synonyms
- 2-Amino-4-Fluorobenz;4-fluoroanthranilaMide;2-Amino-4-fluorobenzamide;Benzamide, 2-amino-4-fluoro-;Benzamide, 2-amino-4-fluoro- (9CI)
- CBNumber
- CB11049805
- Molecular Formula
- C7H7FN2O
- Formula Weight
- 154.14
- MOL File
- 119023-25-5.mol
Benzamide, 2-amino-4-fluoro- (9CI) Property
- Melting point:
- 132 °C(Solv: benzene (71-43-2))
- Boiling point:
- 270.8±25.0 °C(Predicted)
- Density
- 1.344±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 15.69±0.50(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C7H7FN2O/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,9H2,(H2,10,11)
- InChIKey
- OAQNMGCVLKKYJF-UHFFFAOYSA-N
- SMILES
- C(N)(=O)C1=CC=C(F)C=C1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A608300
- Product name
- 2-Amino-4-fluorobenzamide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 084614
- Product name
- 2-Amino-4-fluorobenzamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $488
- Updated
- 2021/12/16
- Product number
- HCH0103713
- Product name
- 2-AMINO-4-FLUOROBENZAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.45
- Updated
- 2021/12/16
- Product number
- FA104622
- Product name
- 2-Amino-4-fluorobenzamide
- Packaging
- 5G
- Price
- $87.5
- Updated
- 2021/12/16
- Product number
- FA104622
- Product name
- 2-Amino-4-fluorobenzamide
- Packaging
- 10g
- Price
- $125
- Updated
- 2021/12/16
Benzamide, 2-amino-4-fluoro- (9CI) Chemical Properties,Usage,Production
Synthesis
446-32-2
119023-25-5
Step A: 2-amino-4-fluorobenzoic acid (4.0 g, 25.8 mmol) was dissolved in degassed DMF (50 mL) under nitrogen protection. HOBt (4.19 g, 31 mmol), DIEA (5.4 mL, 31 mmol), EDCI (5.94 g, 31 mmol), and a methanol solution of 2N ammonia (18 mL, 36.1 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford 2-amino-4-fluorobenzamide as a white solid (2.89 g, 66% yield).1H NMR (300 MHz, DMSO-d6) δ 6.28 (m, 1H), 6.44 (m, 1H), 6.90 (br s, 2H), 7.08 (m, 1H), 7.58 (m, 1H), and 7.71 (br d, 1H).
References
[1] Patent: WO2010/99379, 2010, A1. Location in patent: Page/Page column 135
[2] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 58; 59
[3] Bioorganic and Medicinal Chemistry, 2000, vol. 8, # 3, p. 497 - 506
[4] Patent: US2014/275072, 2014, A1. Location in patent: Paragraph 0132; 0133
[5] Journal of Agricultural and Food Chemistry, 2015, vol. 63, # 31, p. 6883 - 6889
Benzamide, 2-amino-4-fluoro- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, 2-amino-4-fluoro- (9CI) Suppliers
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