3-(1H-Imidazol-4-yl)pyridine

Product Name: 3-(1H-Imidazol-4-yl)pyridine
CAS No.: 51746-85-1
Chemical Name: 3-(1H-Imidazol-4-yl)pyridine
Synonyms: CPD2017;CPDD2017;Brn 0003724;4-(3-Pyridyl)imidazol;4-(3-PYRIDYL)IMIDAZOLE;3-(4-Imidazolyl)Pyridine;3-(1H-IMidazol-5-yl)pyridine;3-(1h-imidazol-4-yl)-pyridin;3-(1H-IMIDAZOL-4-YL)PYRIDINE;3-(5-Imidazolyl)pyridine 95+%
CBNumber: CB1106750
Molecular Formula: C8H7N3
Formula Weight: 145.16
MOL File: 51746-85-1.mol

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3-(1H-Imidazol-4-yl)pyridine Property

Melting point:: 117-118°C
Boiling point:: 422.4±20.0 °C(Predicted)
Density: 1.214±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Ethanol, Methanol, Water
form: Solid
pka: 12.29±0.10(Predicted)
color: Light Yellow
InChI: InChI=1S/C8H7N3/c1-2-7(4-9-3-1)8-5-10-6-11-8/h1-6H,(H,10,11)
InChIKey: YFOKBFRTGLSZLU-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1C1NC=NC=1
CAS DataBase Reference: 51746-85-1(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2933998090
Toxicity: mouse,LD50,intraperitoneal,250mg/kg (250mg/kg),BEHAVIORAL: GENERAL ANESTHETICLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Quarterly Journal of Pharmacy & Pharmacology. Vol. 12, Pg. 260, 1939.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 032282
Product name: 3-(5-Imidazolyl)pyridine
Packaging: 250mg
Price: $144
Updated: 2021/12/16

Matrix Scientific

Product number: 032282
Product name: 3-(5-Imidazolyl)pyridine
Packaging: 1g
Price: $359
Updated: 2021/12/16

AK Scientific

Product number: 7231AB
Product name: 3-(1H-Imidazol-4-yl)pyridine
Packaging: 500mg
Price: $364
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-1-3B
Product name: 3-(5-Imidazolyl)pyridine
Packaging: 1g
Price: $637
Updated: 2021/12/16

Matrix Scientific

Product number: 032282
Product name: 3-(5-Imidazolyl)pyridine
Packaging: 500mg
Price: $233
Updated: 2021/12/16

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3-(1H-Imidazol-4-yl)pyridine Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.

Synthesis

93103-29-8

51746-85-1

General procedure for the synthesis of 3-(1H-imidazol-4-yl)pyridine from the compound (CAS:93103-29-8): 3-(1H-imidazol-4-yl)-4-(pyridin-3-yl)-1H-imidazole-2(3H)-thione (1.0 wt. portion; 1.00 equiv.), which had been prepared in step 3.1, was added to a reactor, followed by the addition of deionized water (8 vols. ). Sodium nitrite (0.58 wt. portions; 1.5 eq.) was added to the reactor, the reaction mixture was cooled to 5 °C and 65% nitric acid (1.97 vol. portions; 5 eq.) was added slowly. The inner wall of the reactor was rinsed with deionized water (2 vol. parts). The reaction mixture is heated to 35°C within 1 hour and stirred at that temperature for not less than 6 hours. In some embodiments, the reaction mixture may be heated to 85°C (e.g., for 3 hours, followed by stirring for an additional 2 hours). The mixture is cooled to 15°C and sodium carbonate (2.0 wt.) (or other base, such as sodium hydroxide) is slowly added. The solution was then heated to 30°C and saturated with sodium chloride. To the aqueous layer is added isopropanol (4 v/v) and stirred for no less than 30 minutes (the temperature may be increased in some embodiments during this process, e.g. to 55/60°C). The phases are separated, sodium chloride (2 wt. portions) is added to the aqueous layer, and the extraction of the aqueous layer is repeated once with isopropanol (4 vol. portions), and once more with isopropanol (2 vol. portions) (other solvents are optional, e.g., 2-methyltetrahydrofuran). The mixture was concentrated under vacuum to 2 vol%. The purity of the product was determined by HPLC and the structure was confirmed by NMR (see Figures 9 and 10). The yield was stable between 84-92% in multiple production runs.

References

[1] Patent: WO2014/17938, 2014, A2. Location in patent: Page/Page column 66

3-(1H-Imidazol-4-yl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1H-Imidazol-4-yl)pyridine Suppliers

Canada 1 China 74 Germany 1 Italy 1 United Kingdom 2 United States 18 Global 97

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View Lastest Price from 3-(1H-Imidazol-4-yl)pyridine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-(1H-Imidazol-4-yl)pyridine 51746-85-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 3-(1H-Imidazol-4-yl)pyridine 51746-85-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

Career Henan Chemical Co

Product: 3-(1H-Imidazol-4-yl)pyridine 51746-85-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

51746-85-1, 3-(1H-Imidazol-4-yl)pyridineRelated Search:

3-(1H-Imidazol-4-yl)pyridine 2-[4-[4-(3-Pyridinyl)-1H-imidazol-1-yl]butyl]-1H-isoindole-1,3(2H)-dione 3-(1H-Imidazol-4-yl)pyridine Dihydrochloride 4-[4-(3-Pyridyl)imidazol-1-yl]butylamine 2-(4-Pyridyl)-4-trifluoromethylimidazole 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine 2-(2-Pyridyl)-4-trifluoromethylimidazole 3-(3H-IMIDAZOL-4-YL)-PYRIDINE 2-(1H-IMIDAZOL-4-YL)-PYRIDINE 2,6-BIS[1-(2-METHYLPHENYLIMINO)ETHYL]PYRIDINE telithromycin 5-(4-FLUORO-PHENYL)-4-PYRIDIN-3-YL-1H-IMIDAZOLE-2-THIOL 5-PYRIDIN-3-YL-1H-IMIDAZOLE-2-THIOL 4-(1H-IMIDAZOL-2-YL)-PYRIDINE 3-FLUORO-2-(1H-IMIDAZOL-2-YL)-PYRIDINE 2-BROMO-3-(1H-IMIDAZOL-2-YL)-PYRIDINE 2-FLUORO-6-(1H-IMIDAZOL-2-YL)-PYRIDINE 2,6-BIS-(1H-IMIDAZOL-2-YL)-PYRIDINE

4-(3-PYRIDYL)IMIDAZOLE

3-(1H-IMIDAZOL-4-YL)PYRIDINE

3-(1h-imidazol-4-yl)-pyridin

3-(5-Imidazolyl)pyridine 95+%

3-(1H-Imidazol-4-yl)pyridineDiscontinued See: I351751

4-(3-Pyridyl)imidazol

Brn 0003724

Pyridine, 3-(1H-imidazol-4-yl)-

3-(1H-IMidazol-5-yl)pyridine

Pyridine, 3-(1H-imidazol-5-yl)-

3-(1H-imidazole-4-yl)pyridine

CPD2017

3-(1H-IMIDAZOL-4-YL)PYRIDINE DISCONTINUED

3-(4-Imidazolyl)Pyridine

CPDD2017

1,4-Benzenedicarbonitrile,2,7-dibromo-

51746-85-1

C8H7N3SHCl

Heterocycles

Miscellaneous Reagents