5-(3-Fluorophenyl)-2-methyl-pyridin
Uses- Product Name
- 5-(3-Fluorophenyl)-2-methyl-pyridin
- CAS No.
- 713143-67-0
- Chemical Name
- 5-(3-Fluorophenyl)-2-methyl-pyridin
- Synonyms
- 5-(3-Fluorophenyl);RSSYY(Iberdomide)-4;5-(3-FLUOROPHENYL)-2-METHYLPYRIDINE;5-(3-Fluorophenyl)-2-methyl-pyridin;Pyridine, 5-(3-fluorophenyl)-2-methyl-
- CBNumber
- CB11075114
- Molecular Formula
- C12H10FN
- Formula Weight
- 187.21
- MOL File
- 713143-67-0.mol
5-(3-Fluorophenyl)-2-methyl-pyridin Property
- Boiling point:
- 284.5±25.0 °C(Predicted)
- Density
- 1.111±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 5.05±0.11(Predicted)
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- PC201289
- Product name
- 5-(3-Fluorophenyl)-2-methylpyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 3H32-3-0P
- Product name
- 5-(3-Fluorophenyl)-2-methylpyridine
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
- Product number
- PC201289
- Product name
- 5-(3-Fluorophenyl)-2-methylpyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $283
- Updated
- 2021/12/16
- Product number
- 3H32-3-0P
- Product name
- 5-(3-Fluorophenyl)-2-methylpyridine
- Purity
- 95.0%
- Packaging
- 5G
- Price
- $453
- Updated
- 2021/12/16
- Product number
- PC201289
- Product name
- 5-(3-Fluorophenyl)-2-methylpyridine
- Purity
- 95+%
- Packaging
- 25g
- Price
- $905
- Updated
- 2021/12/16
5-(3-Fluorophenyl)-2-methyl-pyridin Chemical Properties,Usage,Production
Uses
5-(trifluorophenyl)-2-methylpyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.
Synthesis
768-35-4
111770-91-3
713143-67-0
The general procedure for the synthesis of 5-(3-fluorophenyl)-2-methylpyridine from 3-fluorophenylboronic acid and 6-methyl-3-pyridinol trifluoromethanesulfonate was as follows: 6-methyl-3-pyridinol trifluoromethanesulfonate (6.2 g, 25.7 mmol), 3-fluorophenylboronic acid (4.3 g, 30.7 mmol), potassium carbonate ( 10.7 g, 77.4 mmol) and tetrakis(triphenylphosphine)palladium (297 mg, 0.26 mmol). A solvent mixture of toluene/ethanol/water (4:2:1, 60 mL, v/v) was subsequently added. The reaction mixture was heated to 120 °C and the reaction was stirred at this temperature for 22 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted with the addition of water. The mixture was extracted with ethyl acetate and the organic phase was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10:1) to afford the target product 5-(3-fluorophenyl)-2-methylpyridine (4.3 g, 97% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3): δ 2.62 (s, 3H), 7.04-7.47 (m, 5H), 7.76 (dd, J = 8.1 Hz, 2.4 Hz, 1H), 8.72 (d, J = 2.1 Hz, 1H).
References
[1] Patent: WO2011/162562, 2011, A2. Location in patent: Page/Page column 62
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 11, p. 1054 - 1058
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7166 - 7185
5-(3-Fluorophenyl)-2-methyl-pyridin Preparation Products And Raw materials
Raw materials
Preparation Products
5-(3-Fluorophenyl)-2-methyl-pyridin Suppliers
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