1H-Indole-7-carboxaldehyde, 1-methyl- (9CI)
- Product Name
- 1H-Indole-7-carboxaldehyde, 1-methyl- (9CI)
- CAS No.
- 69047-36-5
- Chemical Name
- 1H-Indole-7-carboxaldehyde, 1-methyl- (9CI)
- Synonyms
- 1-METHYL-1H-INDOLE-7-CARBALDEHYDE;1-Methyl-1H-indole-7-carboxaldehyde;1H-Indole-7-carboxaldehyde, 1-Methyl-;1H-Indole-7-carboxaldehyde, 1-methyl- (9CI)
- CBNumber
- CB11089771
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 69047-36-5.mol
1H-Indole-7-carboxaldehyde, 1-methyl- (9CI) Property
- Melting point:
- 82-84 °C
- Boiling point:
- 318.7±15.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 69047-36-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M337448
- Product name
- 1-Methyl-1H-indole-7-carbaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M337448
- Product name
- 1-Methyl-1H-indole-7-carbaldehyde
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M337448
- Product name
- 1-Methyl-1H-indole-7-carbaldehyde
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CHM0135449
- Product name
- 1-METHYL-1H-INDOLE-7-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $879.25
- Updated
- 2021/12/16
- Product number
- CHM0135449
- Product name
- 1-METHYL-1H-INDOLE-7-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $716.74
- Updated
- 2021/12/16
1H-Indole-7-carboxaldehyde, 1-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
1074-88-0
74-88-4
69047-36-5
GENERAL STEPS: Example I Synthesis of 1-methyl-1H-indole-7-carbaldehyde 20 g of 1H-indole-7-carboxaldehyde was dissolved in 160 ml of N,N-dimethylformamide (DMF) and 15.5 g of potassium tert-butoxide was added in batches under argon protection. After addition, the reaction mixture was stirred for 20 min, followed by slow dropwise addition of 8.7 ml of iodomethane. After the dropwise addition, the reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was partitioned between water and ethyl acetate. The aqueous phase was extracted twice with ethyl acetate. All organic phases were combined and washed with saturated aqueous sodium chloride solution. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was recrystallized from water. The resulting solid was filtered by pumping and dried under vacuum. Yield: 20 g (91% yield). Mass spectrum (ESI+): m/z = 160 [M + H]+.
References
[1] Patent: US2011/269737, 2011, A1. Location in patent: Page/Page column 40
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2060 - 2079
[3] Patent: WO2004/52890, 2004, A1. Location in patent: Page 92-93
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 15, p. 4533 - 4539
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5115 - 5129
1H-Indole-7-carboxaldehyde, 1-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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