Acriflavine hydrochloride
- Product Name
- Acriflavine hydrochloride
- CAS No.
- 69235-50-3
- Chemical Name
- Acriflavine hydrochloride
- Synonyms
- Acid acriflavine;Acriflavine hydrochloride, Fluorescent dye;Acriflavine Hydrochloride (mixture of 3,6-Diamino-10-methylacridinium Chloride Hydrochloride and 3,6-Diaminoacridine Hydrochloride)>
- CBNumber
- CB11106230
- Molecular Formula
- C27H28Cl4N6
- Formula Weight
- 578.36342
- MOL File
- 69235-50-3.mol
Acriflavine hydrochloride Property
- Melting point:
- 240-247°C
- bulk density
- 380kg/m3
- storage temp.
- Store at -20°C
- Water Solubility
- Soluble in water
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Powder
- color
- Orange-red to red-brown
- PH
- 1.0 (20°C, 10g/L in H2O)
- Merck
- 14,123
- Stability:
- Hygroscopic, Light Sensitive
Safety
- RIDADR
- 3077
- Autoignition Temperature
- >190°C
- HS Code
- 2933.99.8290
- HazardClass
- 9
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A0677
- Product name
- Acriflavine Hydrochloride (mixture of 3,6-Diamino-10-methylacridinium Chloride Hydrochloride and 3,6-Diaminoacridine Hydrochloride)
- Purity
- >90.0%(HPLC)
- Packaging
- 25g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- A0677
- Product name
- Acriflavine Hydrochloride (mixture of 3,6-Diamino-10-methylacridinium Chloride Hydrochloride and 3,6-Diaminoacridine Hydrochloride)
- Purity
- >90.0%(HPLC)
- Packaging
- 100g
- Price
- $163
- Updated
- 2025/07/31
- Product number
- 38422
- Product name
- Acriflavinehydrochloride(mixtureof3,6-Diamino-10-methylacridiniumchloridehydrochlorideand3,6-Diaminoacridinehydrochloride),≥90%(HPLC)Hazmat
- Purity
- ≥90%(HPLC)
- Packaging
- 25G
- Price
- $57.08
- Updated
- 2021/12/16
- Product number
- W0003
- Product name
- Acriflavine hydrochloride
- Packaging
- 100g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- CD11071543
- Product name
- Acriflavine hydrochloride
- Purity
- 95+%
- Packaging
- 500g
- Price
- $310
- Updated
- 2021/12/16
Acriflavine hydrochloride Chemical Properties,Usage,Production
Uses
Acriflavine is an topical antiseptic agent and has also been used for the treatment of external fungal infections. Dyes and metabolites.
in vivo
Acriflavine (8 mg/kg; intraperitoneal injection; once a day; 13 administrations) hydrochloride inhibits tumor growth and angiogenesis in NOG mice bearing large HSR-GBM1-Luc cell-derived xenografts[3].
Acriflavine (8 mg/kg; intraperitoneal injection; once a day; 15 administrations) hydrochloride inhibits tumor growth in NOG mice bearing small HSR-GBM1-Luc cell-derived xenografts[3].
Acriflavine (8 mg/kg; intraperitoneal injection; once a day; 10 days of administration) hydrochloride reduces the development of chronic myeloid leukemia and the maintenance of leukemia stem cells in C57BL/6J-CD45.1 mice transplanted with BCR/abl-transduced bone marrow cells[5].
Acriflavine (100 mg/kg orally; 5-15 mg/kg intramuscularly; once a day orally, twice a day intramuscularly; 6 days of administration) hydrochloride inhibits the replication of SARS-CoV-2 in the brain and lungs of K18-ACE2 transgenic mice[6].
| Animal Model: | NOG mice (male and female, 6-8-week-old) with HSR-GBM1-Luc cell - derived xenografts (subcutaneous injection of?HSR-GBM1-Luc cells into the left and right flanks)[3]. |
| Dosage: | 8 mg/kg |
| Administration: | Intraperitoneal injection, once a day, 13 times or 15 times |
| Result: | Inhibited tumor growth. Also reduced tumor microvessel density, indicating inhibition of tumor vascularization. |
| Animal Model: | C57BL/6J-CD45.1 mice (8-10-week-old) with BCR/abl-induced chronic myeloid leukemia (retroviral transduction of BCR/abl into bone marrow cells and transplantation into recipient mice)[5] |
| Dosage: | 8 mg/kg |
| Administration: | Intraperitoneal injection, once a day, 10 days |
| Result: | Reduced splenomegaly, lung infiltrate with myeloid cells, and white blood cell count in peripheral blood. Decreased the percentage and number of?GFP+/CD34-/LSK cells in bone marrow, indicating a reduction in leukemia stem cells. |
| Animal Model: | K18-ACE2 transgenic mice (female, 8-10-week-old) infected with SARS-CoV-2 (intranasal infection with the virus)[6] |
| Dosage: | 100 mg/kg, 5 mg/kg or 15 mg/kg |
| Administration: | Oral administration once a day, intramuscular injection twice a day, 6 days |
| Result: | Blocked the infection in the brain and significantly reduced the viral load in the lungs. The effect was more pronounced with oral administration. |
Acriflavine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Acriflavine hydrochloride Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
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