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CDK1/2InhibitorIII

Product Name
CDK1/2InhibitorIII
CAS No.
443798-55-8
Chemical Name
CDK1/2InhibitorIII
Synonyms
2 Inhibitor III;CDK1/2InhibitorIII;Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III;5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide;1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
CBNumber
CB11113964
Molecular Formula
C15H13F2N7O2S2
Formula Weight
425.44
MOL File
443798-55-8.mol
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CDK1/2InhibitorIII Property

Boiling point:
649.1±65.0 °C(Predicted)
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMSO: 10mg/mL
THF: soluble
acetone: soluble
form 
White solid
pka
6.61±0.70(Predicted)
color 
white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
217714
Product name
Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem
Packaging
1MG
Price
$140
Updated
2023/06/20
Cayman Chemical
Product number
18859
Product name
Cdk1/2 Inhibitor III
Purity
≥95%
Packaging
1mg
Price
$79
Updated
2021/12/16
Cayman Chemical
Product number
18859
Product name
Cdk1/2 Inhibitor III
Purity
≥95%
Packaging
5mg
Price
$315
Updated
2021/12/16
Cayman Chemical
Product number
18859
Product name
Cdk1/2 Inhibitor III
Purity
≥95%
Packaging
10mg
Price
$475
Updated
2021/12/16
TRC
Product number
C228110
Product name
CDK1/2InhibitorIII
Packaging
1mg
Price
$90
Updated
2021/12/16
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CDK1/2InhibitorIII Chemical Properties,Usage,Production

Uses

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).

Uses

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. CDK 1/2 inhibitor III selectively inhibits CDK1 and CDK2. Studies have shown that CDK 1/2 Inhibitor III can also inhibit in vitro cellular proliferation in various human tumor cells.

General Description

A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 μM).

Biochem/physiol Actions

Cell permeable: yes

CDK1/2InhibitorIII Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK1/2InhibitorIII Suppliers

China 10 India 1 United Kingdom 1 United States 6 Global 18
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9804
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10524
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24641
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29981
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
47240
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6743
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58

443798-55-8, CDK1/2InhibitorIIIRelated Search:


  • CDK1/2InhibitorIII
  • 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide
  • 2 Inhibitor III
  • Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III
  • 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
  • 443798-55-8
  • C15H13F2N7O2S2