BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- Product Name
- BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- CAS No.
- 219862-14-3
- Chemical Name
- BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- Synonyms
- BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE;3-(Boc-amino)-1,2,3,4-tetrahydroquinoline;tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl);tert-butyl N-(1,2,3,4-tetrahydroquinolin-3-yl)carbamate;(1,2,3,4-Tetrahydro-quinolin-3-yl)-carbamic acid tert-butyl ester;Carbamic acid, N-(1,2,3,4-tetrahydro-3-quinolinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB1111602
- Molecular Formula
- C14H20N2O2
- Formula Weight
- 248.32
- MOL File
- 219862-14-3.mol
BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Property
- Boiling point:
- 406.8±35.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.04±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P000553241
- Product name
- tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- P000553241
- Product name
- tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate
- Purity
- 97+%
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- P000553241
- Product name
- tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate
- Purity
- 97+%
- Packaging
- 5g
- Price
- $485
- Updated
- 2021/12/16
- Product number
- 1124AB
- Product name
- tert-Butyl(1,2,3,4-tetrahydroquinolin-3-yl)carbamate
- Packaging
- 5g
- Price
- $698
- Updated
- 2021/12/16
- Product number
- CHM0028711
- Product name
- BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $952.01
- Updated
- 2021/12/16
BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Usage,Production
Synthesis
219862-13-2
219862-14-3
The general procedure for the synthesis of tert-butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate from the compound (CAS:219862-13-2) is as follows: to a solution of MeOH (150 mL) of 3-quinolinylcarbamic acid was added a solution of MeOH (18 mL) of 1,1-dimethylethyl ester (6.0 g, 24.56 mmol). The reaction mixture was deoxygenated by argon bubbling for 15 minutes and then palladium hydroxide (20% palladium/carbon, 1.2 g) was added. The resulting suspension was subjected to hydrogenation under 45 psi hydrogen pressure for 16 h. Upon completion of the reaction, the catalyst was removed by filtration. The filtrate was concentrated and the residue was dissolved in dichloromethane (CH2Cl2). The resulting dichloromethane solution was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and saturated aqueous sodium chloride (NaCl), dried over anhydrous sodium sulfate (Na2SO4) and concentrated. Finally, the residue was purified by silica gel column chromatography with gradient elution (0 to 50%) of ethyl acetate (EtOAc) in hexane to afford the target product 1A (4.6 g, 75% yield) as a white solid.
References
[1] Patent: US2006/160850, 2006, A1. Location in patent: Page/Page column 9
[2] Patent: US2012/65204, 2012, A1. Location in patent: Page/Page column 30; 31
[3] Patent: WO2012/31993, 2012, A1. Location in patent: Page/Page column 87
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 7, p. 1895 - 1899
BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Suppliers
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE manufacturers
- Product
- BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 219862-14-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13