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Bornaprolol

Product Name
Bornaprolol
CAS No.
66451-06-7
Chemical Name
Bornaprolol
Synonyms
Bornaprolol;1-[2-(3-bicyclo[2.2.1]heptanyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol;2-Propanol, 1-(2-bicyclo[2.2.1]hept-2-ylphenoxy)-3-[(1-methylethyl)amino]-
CBNumber
CB11116167
Molecular Formula
C19H29NO2
Formula Weight
303.44
MOL File
66451-06-7.mol
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Bornaprolol Property

Boiling point:
460.0±40.0 °C(Predicted)
Density 
1.072±0.06 g/cm3(Predicted)
pka
13.88±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0016582
Product name
BORNAPROLOL
Purity
95.00%
Packaging
5MG
Price
$495.11
Updated
2021/12/16
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Bornaprolol Chemical Properties,Usage,Production

Originator

Bornaprolol hydrochloride,Onbio Inc.

Manufacturing Process

1-Isopropylamino-3-[2-(2-norbornylexo)phenoxy]propan-2-ol:
24.5 g (0.13 moles) 2-(2-norbornylexo)phenol (L. A. KHEIFITS and A. E. GOL'DOVSKII, Zh. Obshch. Khim., 1963, 33, 2048), 350 ml anhydrous toluene and 3 g (0.13 mole) metallic sodium are introduced into a three-neck flask through which a stream of nitrogen flows. The reaction mixture is refluxed until the liberation of hydrogen ceases, then the solvent is driven off under reduced pressure and the residue is taken up in 250 ml tetrahydrofuran. 24 g (0.26 mole) epichlorohydrin are then added and the mixture is heated under reflux for 6 hours. An extraction with ether is then undertaken, the organic phase is washed with water, dried and the solvent is evaporated. 25 g 2-(2- norbornylexo)-1-phenoxy-2,3-epoxypropane are thus obtained in the form of an oil.
15 g (0.06 mole) of the preceding product are dissolved in 50 ml isopropylamine. After 4 days contact, the excess amine is evaporated under reduced pressure, then an extraction with ether is carried out. After washing with water and drying, the ethereal phase is saturated with gaseous hydrochloric acid. The precipitate formed is washed abundantly with ether then crystallized from an acetone/ethanol mixture (3/2). 16 g of the desired product in the form of the hydrochloride are thus obtained, having a melting point of 189°-191°C.

Therapeutic Function

Beta-adrenergic blocker

Bornaprolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Bornaprolol Suppliers

Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58

66451-06-7, BornaprololRelated Search:


  • Bornaprolol
  • 1-[2-(3-bicyclo[2.2.1]heptanyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
  • 2-Propanol, 1-(2-bicyclo[2.2.1]hept-2-ylphenoxy)-3-[(1-methylethyl)amino]-
  • 66451-06-7
  • C19H29NO2