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2-Amino-5-methoxybenzonitrile

Product Name
2-Amino-5-methoxybenzonitrile
CAS No.
23842-82-2
Chemical Name
2-Amino-5-methoxybenzonitrile
Synonyms
6-Amino-m-anisonitrile;2-Cyano-4-methoxyaniline;5-Methoxyanthranilonitrile;2-Amino-5-methoxybenzonitrile;Benzonitrile,2-aMino-5-Methoxy-
CBNumber
CB11118363
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
23842-82-2.mol
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2-Amino-5-methoxybenzonitrile Property

Melting point:
46-47℃
Boiling point:
302℃
Density 
1.17
Flash point:
137℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Low-Melting Solid
pka
2.41±0.10(Predicted)
color 
Pale Yellow to Dark Beige
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Safety

RIDADR 
UN3439
HazardClass 
6.1
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A898645
Product name
2-Amino-5-methoxybenzonitrile
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154914
Product name
2-Amino-5-methoxybenzonitrile
Packaging
250mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154914
Product name
2-Amino-5-methoxybenzonitrile
Packaging
500mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154914
Product name
2-Amino-5-methoxybenzonitrile
Packaging
1g
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154914
Product name
2-Amino-5-methoxybenzonitrile
Packaging
2g
Price
$250
Updated
2021/12/16
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2-Amino-5-methoxybenzonitrile Chemical Properties,Usage,Production

Synthesis

38469-84-0

23842-82-2

Step 2: 2-nitro-5-methoxybenzonitrile (6.5 g, 36 mmol) obtained from Step 1 was dissolved in a 4:1 EtOAc:MeOH solvent mixture (150 mL) in a pressure vessel. Degassing was carried out by bubbling N2 into the solution for 10 min. Subsequently, 10% Pd/C catalyst (300 mg) was added to the solution. The vessel was sealed and pressurized with H2 to 25 psi. the reaction was shaken at room temperature for 20 min. Upon completion of the reaction, the vessel was purged with N2. The reaction mixture was filtered through diatomaceous earth and concentrated. The crude product was purified by fast column chromatography (SiO2 as stationary phase, gradient elution, eluent ratio 100:0 to 60:40 hexane:EtOAc) to afford 2-amino-5-methoxybenzonitrile (6.4 g, 100% yield) as a light yellow solid.

References

[1] Patent: WO2009/5646, 2009, A2. Location in patent: Page/Page column 186
[2] Tetrahedron Letters, 1984, vol. 25, # 8, p. 839 - 842
[3] Organic Preparations and Procedures International, 2009, vol. 41, # 5, p. 423 - 427
[4] Chemistry - A European Journal, 2004, vol. 10, # 10, p. 2487 - 2506
[5] Australian Journal of Chemistry, 1972, vol. 25, p. 2621 - 2629

2-Amino-5-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-methoxybenzonitrile Suppliers

China 105 Germany 1 India 1 United Kingdom 1 United States 8 Global 116
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from 2-Amino-5-methoxybenzonitrile manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Amino-5-methoxybenzonitrile 23842-82-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Career Henan Chemical Co
Product
2-Amino-5-methoxybenzonitrile 23842-82-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2018-12-25

23842-82-2, 2-Amino-5-methoxybenzonitrileRelated Search:

2-Amino-4,5-dimethoxybenzonitrile 4,5-DIMETHOXY-2-NITROBENZONITRILE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(2-METHOXYPHENYL)THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-[3-(TRIFLUOROMETHYL)BENZYL]THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(3,5-DIMETHYLPHENYL)THIOUREA 3-AMINO-3-[4-(6-CHLORO-2-PYRIDINYL)PIPERAZINO]-2-CYANO-N-(2-CYANO-4,5-DIMETHOXYPHENYL)-2-PROPENETHIOAMIDE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-[4-(4-METHYLPIPERAZINO)PHENYL]THIOUREA N-(3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-N'-(2-CYANO-4,5-DIMETHOXYPHENYL)THIOUREA 4,5-DIMETHOXY-2-(5-OXO-2-THIOXO-1-IMIDAZOLIDINYL)BENZENECARBONITRILE 4-[5-CHLORO-1-(3-CHLOROPHENYL)-6-OXO-1,6-DIHYDRO-4-PYRIDAZINYL]-N-(2-CYANO-4,5-DIMETHOXYPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOTHIOAMIDE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-[4-(4-PENTYLCYCLOHEXYL)PHENYL]THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(2-METHOXYETHYL)THIOUREA ETHYL 2-([(2-CYANO-4,5-DIMETHOXYANILINO)CARBOTHIOYL]AMINO)ACETATE 4-([(2-CYANO-4,5-DIMETHOXYANILINO)CARBOTHIOYL]AMINO)-N,N-DIMETHYLBENZENESULFONAMIDE N-(3-CHLOROBENZYL)-N'-(2-CYANO-4,5-DIMETHOXYPHENYL)THIOUREA 5-(2-METHYL(8-QUINOLYLOXY))-2-NITROBENZENECARBONITRILE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(3,4-DICHLOROBENZYL)THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-CYCLOHEXYLTHIOUREA

  • 2-Amino-5-methoxybenzonitrile
  • 6-Amino-m-anisonitrile
  • 2-Cyano-4-methoxyaniline
  • 5-Methoxyanthranilonitrile
  • Benzonitrile,2-aMino-5-Methoxy-
  • 23842-82-2