DL-Menthol
- Product Name
- DL-Menthol
- CAS No.
- 1490-04-6
- Chemical Name
- DL-Menthol
- Synonyms
- MENTHOL;Cyclohexanol, 5-methyl-2-(1-methylethyl)-;menthanol;2-Isopropyl-5-methylcyclohexan-1-ol;1-menthol;2-ISOPROPYL-5-METHYLCYCLOHEXANOL;FEMA 2665;p-Menthan-3-ol;DL-MENTHOL,CRYSTAL,USP;DeMentholised PepperMint Oil
- CBNumber
- CB1116410
- Molecular Formula
- C10H20O
- Formula Weight
- 156.27
- MOL File
- 1490-04-6.mol
DL-Menthol Property
- Melting point:
- 34-36 °C(lit.)
- Boiling point:
- 216 °C(lit.)
- Density
- 0.89 g/mL at 25 °C(lit.)
- vapor pressure
- 0.8 mm Hg ( 20 °C)
- FEMA
- 2665 | MENTHOL RACEMIC
- Flash point:
- 200 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Very soluble in ethanol (95%), chloroform, ether, fatty oils and liquid paraffin; freely soluble in glacial acetic acid;soluble in acetone and benzene; very slightly soluble in glycerin; practically insoluble in water.
- pka
- 15.30±0.60(Predicted)
- form
- Solid
- color
- Clear Colourless
- Odor
- at 10.00 % in dipropylene glycol. cooling mentholic minty
- Odor Type
- mentholic
- JECFA Number
- 427
- Dielectric constant
- 3.2（Ambient）
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- NOOLISFMXDJSKH-UHFFFAOYSA-N
- LogP
- 3.3-3.79 at 25℃
- CAS DataBase Reference
- 1490-04-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Menthol(1490-04-6)
- EPA Substance Registry System
- Menthol (1490-04-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 37/38-41-48/20/22-40-22
- Safety Statements
- 36/37/39-36-26
- RIDADR
- UN 1888 6.1/PG 3
- WGK Germany
- 2
- RTECS
- OT0525000
- HS Code
- 29061100
- Hazardous Substances Data
- 1490-04-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M0350000
- Product name
- Menthol
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- m0350000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 300621
- Product name
- Menthol
- Packaging
- 100mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- orb594111
- Product name
- Menthol
- Packaging
- 1000mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- C6774
- Product name
- Menthol
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0016777
- Product name
- Menthol
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
DL-Menthol Chemical Properties,Usage,Production
Chemical Properties
colourless crystals
Chemical Properties
Racemic menthol is a mixture of equal parts of the (1R,2S,5R)- and (1S,2R,5S)-isomers of menthol. It is a free-flowing or agglomerated crystalline powder, or colorless, prismatic, or acicular shiny crystals, or hexagonal or fused masses with a strong characteristic odor and taste. The crystalline form may change with time owing to sublimation within a closed vessel. The USP 32 specifies that menthol may be either naturally occurring l-menthol or syntheti-cally prepared racemic or dl-menthol. However, the JP XV and PhEur 6.0, along with other pharmacopeias, include two separate monographs for racemic and l-menthol.
Uses
menthol is a fragrance. It is also said to be anti-septic, cooling, refreshing, and a blood-circulation stimulant. Menthol gives the skin a “cool” feeling after use. It constitutes almost 50 percent of peppermint oil but can also be synthetically produced through the hydrogenation of thymol. It is non-toxic in low doses, but in high concentrations it can be irritating to the skin, especially the mucous membranes.
Uses
Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.
Uses
Menthol is used in confectionery, perfumery, cough drops, cigarettes, liqueurs, etc.; topical antipruritic; local anesthetic; gastric sedative.
Definition
A white crystalline terpenealcohol, C10H19OH; r.d. 0.89;m.p. 42°C; b.p. 103–104°C. It has aminty taste and is found in certainessential oils (e.g. peppermint) andused as a flavouring.
Production Methods
Menthol occurs widely in nature as l-menthol and is the principal
component of peppermint and cornmint oils obtained from the
Mentha piperita and Mentha arvensis species. Commercially, lmenthol
is mainly produced by extraction from these volatile oils. It
may also be prepared by partial or total synthetic methods.
Racemic menthol is prepared synthetically via a number of
routes, e.g. by hydrogenation of thymol.
Definition
ChEBI: Any secondary alcohol that is one of the eight possible diastereoisomers of 5-methyl-2-(propan-2-yl)cyclohexan-1-ol.
brand name
Fisherman’s Friend Lozenges (Bristol-Myers Products); Therapeutic Mineral Ice (Bristol-Myers Products).
Pharmaceutical Applications
Menthol is widely used in pharmaceuticals, confectionery, and
toiletry products as a flavoring agent or odor enhancer. In addition
to its characteristic peppermint flavor, l-menthol, which occurs
naturally, also exerts a cooling or refreshing sensation that is
exploited in many topical preparations. Unlike mannitol, which
exerts a similar effect due to a negative heat of solution, l-menthol
interacts directly with the body’s coldness receptors. d-Menthol has
no cooling effect, while racemic menthol exerts an effect approximately
half that of l-menthol.
When used to flavor tablets, menthol is generally dissolved in
ethanol (95%) and sprayed onto tablet granules and not used as a
solid excipient.
Menthol has been investigated as a skin-penetration enhancer
and is also used in perfumery, tobacco products, chewing gum and
as a therapeutic agent. When applied to the skin, menthol dilates the
blood vessels, causing a sensation of coldness followed by an
analgesic effect. It relieves itching and is used in creams, lotions, and
ointments. When administered orally in small doses menthol has a
carminative action.
Safety
Almost all toxicological data for menthol relate to its use as a
therapeutic agent rather than as an excipient. Inhalation or
ingestion of large quantities can result in serious adverse reactions
such as ataxia and CNS depression,hypersensitivity reactions,
severe abdominal pain, nausea, vomiting, vertigo, drowsiness, and
coma.Although menthol is essentially nonirritant there have been
some reports of hypersensitivity following topical application.
In a Polish study approximately 1% of individuals were determined
as being sensitive to menthol.There have been reports of apnea
and instant collapse in infants after the local application of menthol
to their nostrils.
The WHO has set an acceptable daily intake of menthol at up to
0.4 mg/kg body-weight.
LD50 (rat, IM): 10.0 g/kg
LD50 (rat, oral): 3.18 g/kg
storage
A formulation containing menthol 1% w/w in aqueous cream has
been reported to be stable for up to 18 months when stored at room
temperature.
Menthol should be stored in a well-closed container at a
temperature not exceeding 25°C, since it sublimes readily.
Incompatibilities
Incompatible with: butylchloral hydrate; camphor; chloral hydrate; chromium trioxide; b-naphthol; phenol; potassium permanganate; pyrogallol; resorcinol; and thymol.
Regulatory Status
Included in the FDA Inactive Ingredients Database (dental preparations, inhalations, oral aerosols, capsules, solutions, suspensions, syrups, and tablets; also topical preparations). Included in nonparenteral medicines licensed in the UK. Accepted for use in foods and confectionery as a flavoring agent of natural origin. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
DL-Menthol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DL-Menthol manufacturers
- Product
- DL-Menthol 1490-04-6
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-02
- Product
- DL-Menthol 1490-04-6
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-05-20
- Product
- DL-Menthol 1490-04-6
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200000
- Release date
- 2023-11-29