Dihydrodaidzein
- Product Name
- Dihydrodaidzein
- CAS No.
- 17238-05-0
- Chemical Name
- Dihydrodaidzein
- Synonyms
- Dihydrodaidzein>DIHYDRODAIDZEIN hplc;Dihydrodaidzein standard;7-hydroxy-3-(4-hydroxyphenyl)chroman-4-one;7-Hydroxy-3-(4-hydroxyphenyl)-4-chromanone;7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one;inhibit,Endogenous Metabolite,Dihydrodaidzein,Inhibitor;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)-;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one,99%e.e.
- CBNumber
- CB11176286
- Molecular Formula
- C15H12O4
- Formula Weight
- 256.25
- MOL File
- 17238-05-0.mol
Dihydrodaidzein Property
- Melting point:
- 250-251°C
- Boiling point:
- 529.5±50.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- ≤0.1mg/ml in ethanol;30mg/ml in DMSO;10mg/ml in dimethyl formamide
- pka
- 7.71±0.40(Predicted)
- form
- powder to crystal
- color
- Light orange to Yellow to Green
- λmax
- 313nm(EtOH aq.)(lit.)
- CAS DataBase Reference
- 17238-05-0
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SMB00944
- Product name
- Dihydrodaidzein
- Purity
- ≥95%
- Packaging
- 10MG
- Price
- $176
- Updated
- 2024/03/01
- Product number
- SMB00944
- Product name
- Dihydrodaidzein
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $410
- Updated
- 2024/03/01
- Product number
- D4239
- Product name
- Dihydrodaidzein
- Purity
- >93.0%(HPLC)
- Packaging
- 25mg
- Price
- $313
- Updated
- 2024/03/01
- Product number
- 17423
- Product name
- Dihydrodaidzein
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17423
- Product name
- Dihydrodaidzein
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $70
- Updated
- 2024/03/01
Dihydrodaidzein Chemical Properties,Usage,Production
Chemical Properties
Light Beige Needles
Uses
A metabolite of Daidzein.
Uses
Daidzein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes. Dihydrodaidzein is an active, estrogenic metabolite of daidzein. It has vasodilatory action on rat isolated aortic rings at 1 μg/ml. It stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations. Dihydrodaidzein is produced by the metabolism of daidzein in colonic bacteria and may be further metabolized to various bioactive compounds, including equol .
Definition
ChEBI: A hydroxyisoflavanone that is isoflavanone carrying two hydroxy substituents located at positions 4' and 7.
Biological Activity
dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. as an estrogen receptor agonist, dihydrodaidzein, at micromolar concentrations, activates the estrogen receptor-dependent growth of breast cancer cells. daidzein, an isoflavonoid phytoestrogenic compound, is found in soybeans, clover, kudzu, and other legumes.
in vitro
prostatic fluid and plasma concentrations of dihydrodaidzein were sufficient to block the growth of benign human prostatic epithelial cells (prec). dihydrodaidzein showed a significant inhibitory effect on the growth of prostate cancer cell line lncap. additionally, dihydrodaidzein slightly triggered the apoptosis of prec. in addition to affecting apoptosis, dihydrodaidzein decreased proliferation, which was associated with the changes in cell cycle distribution and caspase 3 activation [1].
in vivo
male c57b1/6 wild type mice were administered orally with dihydrodaidzein at a dose of 25 mg/kg/day for 4 weeks. compared to the control groups, the neointima of mice treated with dihydrodaidzein was thickened. in dihydrodaidzein-treated mice, the intimal thickness in the non-injured right iliac artery was not altered. moreover, neointimal proliferation was selectively blocked by dihydrodaidzein via suppressing the migration and proliferation of vascular smooth muscle cell and dampening the endothelial apoptosis [2].
References
[1]. hedlund, t., bokhoven, a., johannes, w., nordeen, s., & ogden, l. prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. the prostate. 2006; 66(5): 557-566.
[2]. shen, j., white, m., husband, a., hambly, b., & bao, s. phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. european journal of pharmacology. 2006; 548(1-3): 123-128.
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Raw materials
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View Lastest Price from Dihydrodaidzein manufacturers
- Product
- Dihydrodaidzein 17238-05-0
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-01-02