ChemicalBook > CAS DataBase List > N-Desethyl Vardenafil

N-Desethyl Vardenafil

Product Name
N-Desethyl Vardenafil
CAS No.
448184-46-1
Chemical Name
N-Desethyl Vardenafil
Synonyms
DESETHYL VARDEFIL;Desethyl vardenafil;Vardenafil-N-desethyl;Vardenafil N-Desethyl Imp;N-Desethyl-N-propylvardenafil;Vardenafil Related Compound E;N-Desethyl Vardenafil Impurity;Vardenafil N-Desethyl Impurity;Vardena hydrochloride impurity E;Vardenafil USP Related Compound E
CBNumber
CB11176569
Molecular Formula
C21H28N6O4S
Formula Weight
460.55
MOL File
448184-46-1.mol
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N-Desethyl Vardenafil Property

Boiling point:
699.8±65.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
DMF: 30mg/mL; DMSO: 30 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/mL
form 
A crystalline solid
pka
7.73±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1711075
Product name
Vardenafil Related Compound E
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1380
Updated
2025/07/31
Cayman Chemical
Product number
9001800
Product name
N-Desethyl Vardenafil
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
9001800
Product name
N-Desethyl Vardenafil
Purity
≥98%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
9001800
Product name
N-Desethyl Vardenafil
Purity
≥98%
Packaging
5mg
Price
$169
Updated
2024/03/01
TRC
Product number
D289950
Product name
N-DesethylVardenafil
Packaging
10mg
Price
$310
Updated
2021/12/16
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N-Desethyl Vardenafil Chemical Properties,Usage,Production

Description

N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5.

Chemical Properties

White to Off-White Solid

Uses

N-Desethyl Vardenafil is a metabolite of Vardenafil, a phosphodiesterase 5 inhibitor.

References

[1] HEI-YOUNG KU. The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil.[J]. Drug Metabolism and Disposition, 2008, 36 6: 986-990. DOI: 10.1124/dmd.107.020099

N-Desethyl Vardenafil Preparation Products And Raw materials

Raw materials

Preparation Products

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448184-46-1, N-Desethyl VardenafilRelated Search:

Vardenafil IMpurity 2 Hydroxyvardenafil Vardenafil Impurity 7 Vardenafil IMpurity 3 Hydroxythiovardenafil Vardenafil Oxopiperazine (IMpurity) 3-(1,4-Dihydro-5-Methyl-4-oxo-7-propyliMidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxybenzoic Acid Vardenafil Impurity 15 Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[5-[(4-ethyl-1-piperazinyl)sulfonyl]-2-propoxyphenyl]-5-methyl-7-propyl- Vardenafil Impurity 15 3-(1,4-Dihydro-5-Methyl-4-oxo-7-propyliMidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxybenzenesulfonic Acid Vardenafil Impurity 5 2,2'-((piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene))bis(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one) 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE 7-Despropyl 7-Methyl Vardenafil Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[5-[(4-ethyl-1-piperazinyl)sulfonyl]-2-hydroxyphenyl]-5-methyl-7-propyl- Vardenafil IMpurity 1 Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-

  • 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-piperazine
  • Vardenafil Impurity 4(Vardenafil N-Desethyl Impurity)
  • 2-(2-ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
  • Vardenafil N-Desethyl Impurity
  • Vardenafil N-Desethyl Imp
  • N-Desethyl Vardenafil Impurity
  • 2-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
  • 2-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
  • Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-(1-piperazinylsulfonyl)phenyl]-5-methyl-7-propyl-
  • Desethyl vardenafil
  • N-Desethyl VardenafilQ: What is N-Desethyl Vardenafil Q: What is the CAS Number of N-Desethyl Vardenafil Q: What is the storage condition of N-Desethyl Vardenafil Q: What are the applications of N-Desethyl Vardenafil
  • Vardena hydrochloride impurity E
  • N-Desethyl-N-propylvardenafil
  • Vardenafil Related Compound E
  • Vardenafil USP Related Compound E
  • DESETHYL VARDEFIL
  • Vardenafil USP Related Compound E (N-Desethyl Vardenafil)
  • Vardenafil-N-desethyl
  • N-Desethyl Vardenafil in Methanol
  • Vardenafil Impurity 4 (N-Desethyl Vardenafil)
  • 448184-46-1
  • Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals