Brofaromine
- Product Name
- Brofaromine
- CAS No.
- 63638-91-5
- Chemical Name
- Brofaromine
- Synonyms
- 4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine;Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-;4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
- CBNumber
- CB11178149
- Molecular Formula
- C14H16BrNO2
- Formula Weight
- 310.19
- MOL File
- 63638-91-5.mol
Brofaromine Property
- Boiling point:
- 404.0±45.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (805.96 mM)
- form
- Solid
- pka
- 9.99±0.10(Predicted)
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- CS-6637
- Product name
- Brofaromine
- Purity
- 98.55%
- Packaging
- 5mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- CS-6637
- Product name
- Brofaromine
- Purity
- 98.55%
- Packaging
- 10mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- CS-6637
- Product name
- Brofaromine
- Purity
- 98.55%
- Packaging
- 50mg
- Price
- $980
- Updated
- 2021/12/16
- Product number
- CS-6637
- Product name
- Brofaromine
- Purity
- 98.55%
- Packaging
- 100mg
- Price
- $1500
- Updated
- 2021/12/16
Brofaromine Chemical Properties,Usage,Production
Biological Activity
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor, inhibits MAO-A with IC50 of 0.2 μM.
in vitro
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM.
target
IC50: 0.2 μM (MAO-A)
Brofaromine Preparation Products And Raw materials
Raw materials
Preparation Products
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