Chimaphilin

Product Name: Chimaphilin
CAS No.: 482-70-2
Chemical Name: Chimaphilin
Synonyms: 7-Dimethyl-1;2,7-dimethylnaphthalene-1,4-dione;2,7-Dimethyl-1,4-naphthalenedione;1,4-Naphthalenedione, 2,7-dimethyl-
CBNumber: CB11178255
Molecular Formula: C12H10O2
Formula Weight: 186.21
MOL File: 482-70-2.mol

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Chimaphilin Property

Melting point:: 113.5-114.5°; mp 232-233°
Boiling point:: 346.8±42.0 °C(Predicted)
Density: 1.187

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0002103
Product name: CHIMAPHILIN
Purity: 95.00%
Packaging: 5MG
Price: $501.67
Updated: 2021/12/16

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Chimaphilin Chemical Properties,Usage,Production

Uses

Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].

Definition

ChEBI: Chimaphylin is a member of 1,4-naphthoquinones.

References

[1] Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30. DOI:10.1016/j.cbi.2015.05.008
[2] Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8. DOI:10.1016/j.fct.2014.04.014

Chimaphilin Preparation Products And Raw materials

Raw materials

Preparation Products

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2,7-Dimethyl-1,4-naphthalenedione

2,7-dimethylnaphthalene-1,4-dione

7-Dimethyl-1

1,4-Naphthalenedione, 2,7-dimethyl-

482-70-2