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ACETYLDIGITOXIN

Product Name
ACETYLDIGITOXIN
CAS No.
1111-39-3
Chemical Name
ACETYLDIGITOXIN
Synonyms
adicin;a-Form;acylanid;Acedigal;ACETYLDIGITOXIN;Acetildigitoxina;Acetyldigitoxinum;3'''-Acetyldigitoxin;alpha-acetyldigitoxin;acetyl-digitoxin-alpha
CBNumber
CB1117871
Molecular Formula
C43H66O14
Formula Weight
806.98
MOL File
1111-39-3.mol
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ACETYLDIGITOXIN Property

Melting point:
217-221°
alpha 
D20 +5.0° (c = 0.7 in pyridine)
Boiling point:
673.84°C (rough estimate)
Density 
1.1009 (rough estimate)
refractive index 
1.6130 (estimate)
storage temp. 
Store at -20°C
solubility 
Chloroform: Slightly Soluble; DMSO: Slightly Soluble; Methanol: Slightly Soluble
form 
A solid
Stability:
Hygroscopic
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Safety

RIDADR 
3249
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24024
Product name
Acetyldigitoxin
Purity
≥95%
Packaging
500μg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
24024
Product name
Acetyldigitoxin
Purity
≥95%
Packaging
1mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
24024
Product name
Acetyldigitoxin
Purity
≥95%
Packaging
5mg
Price
$1175
Updated
2024/03/01
TRC
Product number
D445385
Product name
Digitoxin3''''''-Acetate
Packaging
1mg
Price
$215
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015035
Product name
ACETYLDIGITOXIN
Purity
95.00%
Packaging
5MG
Price
$496.31
Updated
2021/12/16
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ACETYLDIGITOXIN Chemical Properties,Usage,Production

Originator

Acylanid ,Sandoz ,US ,1954

Uses

Digitoxin 3'''-Acetate is a derivative of Digitoxin (D445950) which is cardotonic.

Definition

ChEBI: 3'''-O-acetyldigitoxin is a cardenolide glycoside compound consisting of digitoxin having an acetyl substituent at the 3-position on the D-ribo-hexopyranosyl residue at the non-reducing end. It has a role as an anti-arrhythmia drug, a cardiotonic drug and an enzyme inhibitor. It is functionally related to a digitoxin.

Manufacturing Process

Acetyldigitoxin-α can be obtained from acetyldigitoxin-β by heating it in an anhydrous or aqueous organic solvent at neutral, weakly acid or weakly alkaline pH, i.e., at a pH range from about 3.5 to about 8.
The acetylidigitoxin-β used for this purpose is a cardiac glycoside which can be obtained either by splitting off the glucose residue from lanatoside A, or by extraction of the leaves of Digitalis ferrugines. It is composed of the aglycone digitoxigenin and 3 molecules of digitoxose, to one of which an acetyl group is attached. Acetyldigitoxin-α, obtained from acetyldigitoxin-β by rearrangement, differs from the latter in the position of the acetyl group.
The process may be carried out, for example, in the following manner: A solution of acetyldigitoxin-β in a suitable solvent, such as methanol, is boiled under reflux and then diluted with water. The unchanged acetyldigitoxin-β, which crystallizes out first, is filtered off and can again be submitted to the same process. On concentrating the filtrate, acetyldigitoxin-α separates out in crystalline form and after filtering off and recrystallizing is obtained in a pure state. The acetyldigitoxin-α crystallizes from aqueous methanol in platelets melting at 217-221°C.

brand name

Acylanid (Novartis).

Therapeutic Function

Cardiotonic

Purification Methods

-Acetyldigitoxin is obtained from the commercial mixture [ : (2:1)] [25395-32-8]. The form is obtained from the form by heating in anhydrous or aqueous organic solvent (e.g. aqueous MeOH) at pH 3.5—8. It crystallises from MeOH as plates, CHCl3/Et2O or Me2CO/Et2O. At 20o 1g dissolves in 16mL of MeOH, 66mL of Me2CO and ~880mL of EtOAc. [Stoll & Kreis Helv Chim Acta 35 1318, 1322 1952, Beilstein 18 III/IV 1479.] It is a cardenolide.C5128

ACETYLDIGITOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ACETYLDIGITOXIN Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44808
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Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
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58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-61856358 15229202216
Fax
029-88380327
Email
1020@dideu.com
Country
China
ProdList
10007
Advantage
58
Beijing Biocreative Technology Co., Ltd.
Tel
15522676233
Email
3007606172@qq.com
Country
China
ProdList
1248
Advantage
58

1111-39-3, ACETYLDIGITOXINRelated Search:


  • acetate,alpha-digitoxi
  • acetyl-digitoxin-alpha
  • acylanid
  • adicin
  • alpha-acetyldigitoxin
  • 3'''-Acetyldigitoxin
  • 3β-[[4-O-[4-O-(3-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-14-hydroxy-5β-card-20(22)-enolide
  • Acedigal
  • Acetildigitoxina
  • Acetildigitoxina [inn-spanish]
  • Acetyldigitoxinum
  • Acetyldigitoxinum [inn-latin]
  • a-Form
  • HPMZBILYSWLILX-JYCQOZIASA-N
  • Digitoxin 3'''-Acetate
  • ACETYLDIGITOXIN
  • Card-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
  • ACETYLDIGITOXIN USP/EP/BP
  • 3'''-O-acetyldigitoxin
  • 1111-39-3
  • C43H66O14