ChemicalBook > CAS DataBase List > 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-

Product Name
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
CAS No.
222631-44-9
Chemical Name
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
Synonyms
BCX 4430;Galidesivir);Galidesivir HCl;BCX-4430 (BCX4430;BCX4430;GALIDESIVIR;BCX 4430 hydrochloride;Galidesivir hydrochloride;Immucillin-A hydrochloride;GALIDESIVIR HYDROCHLORIDE (BCX 4430 HYDROCHLORIDE);(2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol monohydrochloride
CBNumber
CB11211297
Molecular Formula
C11H16ClN5O3
Formula Weight
301.73
MOL File
222631-44-9.mol
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3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- Property

storage temp. 
Store at -20°C
solubility 
H2O: 2 mg/mL, clear
form 
Solid
color 
White to off-white
Water Solubility 
Water : ≥ 41 mg/mL (135.88 mM)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B119190
Product name
BCX4430
Packaging
10mg
Price
$31350
Updated
2021/12/16
ChemScene
Product number
CS-3778
Product name
Galidesivir(hydrochloride)
Purity
99.88%
Packaging
1mg
Price
$600
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611553
Product name
BCX-4430
Packaging
5mg
Price
$2395.3
Updated
2021/12/16
ChemScene
Product number
CS-3778
Product name
Galidesivir(hydrochloride)
Purity
99.88%
Packaging
5mg
Price
$2400
Updated
2021/12/16
Crysdot
Product number
CD31002620
Product name
BCX4430
Purity
98+%
Packaging
5mg
Price
$1389
Updated
2021/12/16
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3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- Chemical Properties,Usage,Production

Uses

BCX 4430 is an antiviral drug, an adenosine analog). It is developed by BioCryst Pharmaceuticals with funding from NIAID, originally intended as a treatment for Hepatitis C, but subsequently developed as a potential treatment for deadly filovirus infections such as Ebola virus disease and Marburg virus disease.

in vivo

Galidesivir (BCX4430) hydrochloride is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir hydrochloride has demonstrated pronounced efficacy[1].
Galidesivir hydrochloride (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)[4].

Animal Model:Female Syrian golden hamsters (hamsters infected with YF virus)[4]
Dosage:4 mg/kg of body weight
Administration:I.p.; twice daily for 7 days
Result:Significantly improved the survival of hamsters infected with YFV.

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- Suppliers

China 35 United States 9 Global 44
BOC Sciences
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1-631-485-4226; 16314854226
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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LETOPHARM LIMITED
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+86-21-5106 2861
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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View Lastest Price from 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- manufacturers

Wuhan Monad Medicine Tech Co.,LTD
Product
BCX-4430 222631-44-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99%
Supply Ability
20 tons/month
Release date
2020-12-25
Career Henan Chemical Co
Product
3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- 222631-44-9
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

222631-44-9, 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-Related Search:

N,N-DIETHYLBENZAMIDE Aspartate aminotransferase

  • 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
  • 3,4-Pyrrolidinediol,2-(4-aMino-5H-pyrrolo[3,2-d]pyriMidin-7-yl)-5-(hydroxyMethyl)-, hydrochloride(1:1), (2S,3S,4R,5R)-
  • BCX 4430
  • (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol monohydrochloride
  • BCX-4430 (BCX4430
  • Galidesivir)
  • BCX4430;GALIDESIVIR
  • GALIDESIVIR HYDROCHLORIDE (BCX 4430 HYDROCHLORIDE)
  • Galidesivir hydrochloride
  • Galidesivir HCl
  • BCX 4430 hydrochloride
  • Immucillin-A hydrochloride
  • 222631-44-9
  • C11H15N5O3HCl