ChemicalBook > CAS DataBase List > Asiaol-Gm1-tetrasaccharide
Asiaol-Gm1-tetrasaccharide
- Product Name
- Asiaol-Gm1-tetrasaccharide
- CAS No.
- 75645-24-8
- Chemical Name
- Asiaol-Gm1-tetrasaccharide
- Synonyms
- Gangliotetraose;Asiaol-Gm1-tetrasaccharide;Asialo GM1 Ganglioside oligosaccharide (aGM1) (>90% NMR) Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) grafted on BSA Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) grafted on HSA Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) grafted on KLH Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) grafted on OVA Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) grafted on CRM197 Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) with DBCO (Linker-DBCO A) Sodium salt;Asialo GM1 Ganglioside oligosaccharide (aGM1) linked to biotin (Linker-BT C) Sodium salt
- CBNumber
- CB11231824
- Molecular Formula
- C26H45NO21
- Formula Weight
- 707.63
- MOL File
- 75645-24-8.mol
More
Less
Asiaol-Gm1-tetrasaccharide Property
- Boiling point:
- 1173.6±65.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- pka
- 12.39±0.20(Predicted)
More
Less
N-Bromosuccinimide Price
Usbiological
- Product number
- 297014
- Product name
- Gangliotetraose
- Packaging
- 250ug
- Price
- $545
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 108120
- Product name
- Gangliotetraose
- Packaging
- 2mg
- Price
- $570
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- OG03927
- Product name
- Gangliotetraose
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
AK Scientific
- Product number
- 1673CB
- Product name
- N-[(2S,3R,4R,5R,6R)-2-[(2R,3R,4R,5R,6S)-4,5-Dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
- Packaging
- 10mg
- Price
- $860
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- OG03927
- Product name
- Gangliotetraose
- Packaging
- 500ug
- Price
- $60
- Updated
- 2021/12/16
More
Less
Asiaol-Gm1-tetrasaccharide Chemical Properties,Usage,Production
Uses
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].
in vivo
Gangliotetraose (GM1) (30 mg/kg; i.p.; 5, 11, 42, and 73 d) stimulates the regeneration of nigrostriatal dopaminergic neurons in the central nervous system of rats after unilateral hemitransection[5].
| Animal Model: | Unilateral semi-transection model in Sprague-Dawley rats (170-190 g)[5] |
| Dosage: | 5 mg/kg; 30 mg/kg |
| Administration: | Intraperitoneal injection; 5, 11, 42, 73 days; started on day 2 after surgery and finished 24 h before sacrifice |
| Result: | Increased the Vmax of tyrosine hydroxylase (TH) in the lesioned side starting on day 14 dose-dependently with 73% (5 mg/kg/d) and 85% (30 mg/kg/d) of that of the unlesioned side, respectively. |
References
[1] Okada H, et al. Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression. Int Immunol. 1998 Jan;10(1):91-5. DOI:10.1093/intimm/10.1.91
[2] Ledeen RW, et al. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci. 1998 Jun 19;845:161-75. DOI:10.1111/j.1749-6632.1998.tb09669.x
[3] Zakharova IO, et al. GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. Neurochem Res. 2014 Nov;39(11):2262-75. DOI:10.1007/s11064-014-1428-6
[4] Toffano G, et al. GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system. Brain Res. 1983 Feb 14;261(1):163-6. DOI:10.1016/0006-8993(83)91298-2
Asiaol-Gm1-tetrasaccharide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Asiaol-Gm1-tetrasaccharide Suppliers
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 16314854226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 9713
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Country
- China
- ProdList
- 9650
- Advantage
- 58
- Tel
- 15102117276 19921389125
- tech@zzbioco.com
- Country
- China
- ProdList
- 12064
- Advantage
- 58
- Tel
- 15317051735
- zhaojing@wytsci.com
- Country
- China
- ProdList
- 9980
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 021-60936350
- scbt@scbt.com
- Country
- China
- ProdList
- 6594
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
75645-24-8, Asiaol-Gm1-tetrasaccharideRelated Search:
BODIPY(R) FL C5-GANGLIOSIDE GM1 COMPLEXED TO BSA
Asiaol-Gm1-tetrasaccharide
Siagoside
LYSO-GANGLIOSIDE GM1, BOVINE
Mipragoside
LIGA 20
DISIALOGANGLIOSIDE GD1B 2NA
TRISIALOGANGLIOSIDE GT1B 3NA
GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE