ChemicalBook > CAS DataBase List > CP-4126 (LVT derivative of Gemcitabine)

CP-4126 (LVT derivative of Gemcitabine)

Product Name: CP-4126 (LVT derivative of Gemcitabine)
CAS No.: 210829-30-4
Chemical Name: CP-4126 (LVT derivative of Gemcitabine)
Synonyms: CS-1569;CP 4126;GeMcitabine elaidate;GeMcitabine 5'-elaidate;Gemcitabine elaidate(CP-4126;CO-101:CP-4126:Gemcitabineelaidate;Gemcitabine elaidate，CO-101，CP-4126;CP-4126 (LVT derivative of Gemcitabine);CO-101; CP-4126; GEMCITABINE 5'-ELAIDATE;Gemcitabine elaidate (Anti oleic acid gemcitabine)
CBNumber: CB11231859
Molecular Formula: C27H43F2N3O5
Formula Weight: 527.64
MOL File: 210829-30-4.mol

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CP-4126 (LVT derivative of Gemcitabine) Property

Boiling point:: 631.4±65.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.63(Max Conc. mM)
DMSO:28.0(Max Conc. mg/mL);53.07(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);56.86(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);56.86(Max Conc. mM)
form: A crystalline solid
pka: 11.48±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28303
Product name: Gemcitabine Elaidate
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 28303
Product name: Gemcitabine Elaidate
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 28303
Product name: Gemcitabine Elaidate
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 28303
Product name: Gemcitabine Elaidate
Packaging: 10mg
Price: $214
Updated: 2024/03/01

ChemScene

Product number: CS-3744
Product name: Gemcitabine(elaidate)
Purity: 99.24%
Packaging: 5mg
Price: $126
Updated: 2021/12/16

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CP-4126 (LVT derivative of Gemcitabine) Chemical Properties,Usage,Production

Uses

Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity[1][2].

Definition

ChEBI: Gemcitabine elaidate is a pyrimidine 2'-deoxyribonucleoside.

in vivo

Gemcitabine elaidate (25-120 mg/kg; i.p. every 3 days for 5 doses) inhibits the solid tumor xenografts growth of non-small cell lung cancer (EKVX), non-classifiable sarcoma (MHMX), fibrous histiocytoma (TAX II-1), malignant melanoma (THX), prostate cancer (CRL-1435), pancreatic cancer (PANC-1)^[1].
Gemcitabine elaidate (10-20 mg/kg; p.o. every 3 days for 5 doses) shows acceptable toxicity and significant antitumor activity in the colon cancer xenograft Co6044 bearing mice^[1].
Gemcitabine elaidate (p.o. once daily for 5 doses) shows a favorable toxicity and antitumor activity, while the dose of 15 mg/kg is highly toxic in the human colon cancer xenograft Co6044^[1].

Animal Model:	Female BALB/c nude (nu/nu) mice (5-8 weeks; 20-27 g) were bearing tumor of EKVX, H-146, MHMX, TAX II-1, OHS, THX, MA-11, CRL-1435, PANC-1 and MiaPaCa-2, respectively^[1]
Dosage:	25-120 mg/kg
Administration:	I.p. every 3 days for 5 doses
Result:	Inhibited the growth of EKVX, MHMX, TAX II-1, THX, CRL-1435 and PANC-1, with T/C values of 7%, 1%, 30%, 7%, 9%, and 12%, respectively.

References

[1] Bergman AM, et, al. Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Invest New Drugs. 2011 Jun;29(3):456-66. DOI:10.1007/s10637-009-9377-7
[2] Adema AD, et, al. Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. Int J Oncol. 2010 Jan;36(1):285-94. PMID:19956857

CP-4126 (LVT derivative of Gemcitabine) Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-4126 (LVT derivative of Gemcitabine) Suppliers

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View Lastest Price from CP-4126 (LVT derivative of Gemcitabine) manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: CP-4126 (LVT derivative of Gemcitabine) 210829-30-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gemcitabine elaidate 210829-30-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gemcitabine elaidate 210829-30-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

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210829-30-4

C27H43F2N3O5