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(1,2,4)Triazolo(1,5-a)pyrazine

Product Name
(1,2,4)Triazolo(1,5-a)pyrazine
CAS No.
399-66-6
Chemical Name
(1,2,4)Triazolo(1,5-a)pyrazine
Synonyms
(1,2,4)Triazolo(1,5-a)pyrazine
CBNumber
CB11236667
Molecular Formula
C5H4N4
Formula Weight
120.11
MOL File
399-66-6.mol
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(1,2,4)Triazolo(1,5-a)pyrazine Property

Melting point:
125-126 °C
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at room temperature
pka
0.08±0.30(Predicted)
Appearance
Off-white to light brown Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T796258
Product name
[1,2,4]Triazolo[1,5-A]pyrazine
Packaging
100mg
Price
$90
Updated
2021/12/16
Activate Scientific
Product number
AS147578
Product name
[1,2,4]Triazolo[1,5-a]pyrazine
Purity
95%
Packaging
1g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
5277AB
Product name
[1,2,4]Triazolo[1,5-a]pyrazine
Packaging
1g
Price
$264
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0380009
Product name
[1,2,4]TRIAZOLO[1,5-A]PYRAZINE
Purity
95.00%
Packaging
5MG
Price
$504.15
Updated
2021/12/16
AK Scientific
Product number
5277AB
Product name
[1,2,4]Triazolo[1,5-a]pyrazine
Packaging
5g
Price
$764
Updated
2021/12/16
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(1,2,4)Triazolo(1,5-a)pyrazine Chemical Properties,Usage,Production

Synthesis

51519-20-1

399-66-6

The general procedure for the synthesis of [1,2,4]triazolo[1,5-a]pyrazines from the compound (CAS:51519-20-1) is as follows: polyphosphoric acid (250 g) was added to (Z)-N'-hydroxy-N-(pyrazin-2-yl)carbamoylamide (25.07 g, 181 mmol), followed by immediately heating the reaction mixture to 90 °C. The reaction mixture was kept stirred at this temperature for 4 hours. After completion of the reaction, the hot reaction mixture was slowly poured into ice water and the pH was adjusted to basic with sodium bicarbonate. Subsequently, the aqueous phase was extracted with dichloromethane (1 L, followed by 3 x 0.5 L). All organic phases were combined and dried with anhydrous sodium sulfate (Na2SO4), after which the organic phase was concentrated. The crude product was purified by batch crystallization from ethanol. A final product of 18.10 g was obtained in 83% yield.

References

[1] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 68

(1,2,4)Triazolo(1,5-a)pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(1,2,4)Triazolo(1,5-a)pyrazine Suppliers

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  • (1,2,4)Triazolo(1,5-a)pyrazine
  • 399-66-6