1,4-dioxaspiro[4.5]decan-9-one

Product Name: 1,4-dioxaspiro[4.5]decan-9-one
CAS No.: 4969-01-1
Chemical Name: 1,4-dioxaspiro[4.5]decan-9-one
Synonyms: 1,4-Dioxaspiro[4.5]decan-7-one;1,4-dioxaspiro[4.5]decan-9-one;1, 4-DI0XASPIR0[4. 5]DECAN-T- ONE;1,4-Dioxaspiro[4.5]decan-7-one - [D13531]
CBNumber: CB11255217
Molecular Formula: C8H12O3
Formula Weight: 156.18
MOL File: 4969-01-1.mol

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1,4-dioxaspiro[4.5]decan-9-one Property

Boiling point:: 103-108 °C(Press: 4.5 Torr)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C8H12O3/c9-7-2-1-3-8(6-7)10-4-5-11-8/h1-6H2
InChIKey: TVXYCOHQUCHFAM-UHFFFAOYSA-N
SMILES: O1C2(CCCC(=O)C2)OCC1
CAS DataBase Reference: 4969-01-1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: D486290
Product name: 1,4-Dioxaspiro[4,5]decan-7-one
Packaging: 5g
Price: $1485
Updated: 2021/12/16

Oakwood

Product number: 043881
Product name: 1,4-Dioxa-spiro[4.5]decan-7-one
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Oakwood

Product number: 043881
Product name: 1,4-Dioxa-spiro[4.5]decan-7-one
Packaging: 1g
Price: $139
Updated: 2021/12/16

Matrix Scientific

Product number: 123545
Product name: 1,4-Dioxaspiro[4.5]decan-7-one
Purity: 95+%
Packaging: 1g
Price: $148
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD170792
Product name: 1,4-Dioxaspiro[4.5]decan-7-one
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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1,4-dioxaspiro[4.5]decan-9-one Chemical Properties,Usage,Production

Uses

1,4-Dioxaspiro[4,5]decan-7-one is a chemical reagent used in the preparation of rhodesain inhibitors which combat trypanosoma brucei parasites.

Synthesis

504-02-9

107-21-1

4969-01-1

1. Cyclohexane-1,3-dione (500 g, 4.459 mol), 4A molecular sieves (500 g, 4.459 mol) and p-toluenesulfonic acid (254 g, 1.338 mol) were dissolved in anhydrous ethylene glycol (2 L) under nitrogen protection. 2. The reaction mixture was stirred at room temperature for 4 hours. 3. After completion of the reaction, the reaction mixture was adjusted to an alkaline pH with saturated NaHCO3 solution (1 L). 4. Extract the basic mixture with ethyl acetate (3 × 1 L). 5. 5. The organic phases were combined and washed with brine solution (500 mL) and subsequently dried with Na2SO4. 6. The dried organic phase was filtered and concentrated under reduced pressure to afford 1,4-dioxaspiro[4.5]decan-7-one (280 g, 1.732 mol, 38.8% yield) as a yellow liquid. 7. The product was confirmed by LCMS, m/z 157.1 (M + H+).

References

[1] Journal of Mass Spectrometry, 1998, vol. 33, # 3, p. 229 - 241
[2] Synthetic Communications, 1999, vol. 29, # 18, p. 3097 - 3106
[3] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 13, p. 1885 - 1892
[4] Journal of the Chemical Society, Chemical Communications, 1993, # 4, p. 364 - 365
[5] Journal of the American Chemical Society, 1986, vol. 108, # 24, p. 7575 - 7579

1,4-dioxaspiro[4.5]decan-9-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-dioxaspiro[4.5]decan-9-one Suppliers

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4969-01-1, 1,4-dioxaspiro[4.5]decan-9-oneRelated Search:

1,4-dioxaspiro[4.5]decan-9-one

1,4-Dioxaspiro[4.5]decan-7-one

1, 4-DI0XASPIR0[4. 5]DECAN-T- ONE

1,4-Dioxaspiro[4.5]decan-7-one - [D13531]

4969-01-1

4746-97-9