ChemicalBook > CAS DataBase List > Tiplaxtinin

Tiplaxtinin

Product Name
Tiplaxtinin
CAS No.
393105-53-8
Chemical Name
Tiplaxtinin
Synonyms
PAI-039;CS-1464;tiplasinin;Tiplaxtinin;PAI 039 Tiplaxtinin;TIPLAXTININ(PAI-039);Tiplaxtinin >=98% (HPLC);Tiplaxtinin(PAI-039), >98%;TIPLAXTININ;PAI039;PAI 039;2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
CBNumber
CB11261085
Molecular Formula
C24H16F3NO4
Formula Weight
439.38
MOL File
393105-53-8.mol
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Tiplaxtinin Property

Melting point:
164-167℃
Density 
1.34
storage temp. 
-20°C
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0295
Product name
Tiplaxtinin
Purity
≥98% (HPLC)
Packaging
5MG
Price
$115
Updated
2023/06/20
Sigma-Aldrich
Product number
PZ0295
Product name
Tiplaxtinin
Purity
≥98% (HPLC)
Packaging
25MG
Price
$451
Updated
2023/06/20
Cayman Chemical
Product number
9000450
Product name
Tiplaxtinin
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
9000450
Product name
Tiplaxtinin
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
9000450
Product name
Tiplaxtinin
Purity
≥98%
Packaging
10mg
Price
$142
Updated
2024/03/01
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Tiplaxtinin Chemical Properties,Usage,Production

Description

Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 μM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 μM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.

Uses

Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.

Definition

ChEBI: Tiplasinin is a member of indole-3-acetic acids. It is a potent and selective PAI-1 inhibitor. Tiplaxtinin demonstrated efficacy in vivo in multiple models of acute arterial thrombosis and has been shown to reduce physiologic PAI-1 activity.

Biochem/physiol Actions

Tiplaxtinin has high oral bioavailability. It is metabolically stable and shows large safety multiples in animal toxicology studies. Tiplaxtinin can be easily synthesized in bulk quantities. This drug also reduces diet-induced obesity in mice.

storage

Store at +4°C

Tiplaxtinin Preparation Products And Raw materials

Raw materials

Preparation Products

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Tiplaxtinin Suppliers

China 90 India 1 United Kingdom 1 United States 17 Global 109
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View Lastest Price from Tiplaxtinin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Tiplaxtinin 393105-53-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tiplaxtinin 393105-53-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d 393105-53-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

393105-53-8, TiplaxtininRelated Search:

(S)-(+)-Benzyl glycidyl ether Poly(methyl methacrylate) Benzyl alcohol TRIMETHYLPHOSPHINE OXIDE 4'-Hydroxyacetophenone

  • 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid
  • TIPLAXTININ(PAI-039)
  • 1H-Indole-3-aceticacid, a-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
  • 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
  • tiplasinin
  • Tiplaxtinin
  • PAI-039
  • alpha-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
  • PAI 039 Tiplaxtinin
  • Tiplaxtinin(PAI-039), >98%
  • α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
  • CS-1464
  • TIPLAXTININ;PAI039;PAI 039
  • 1H-Indole-3-acetic acid, α-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
  • Tiplaxtinin >=98% (HPLC)
  • 393105-53-8
  • C24H16F3NO4
  • Inhibitors