tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

Product Name: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate
CAS No.: 154590-34-8
Chemical Name: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate
Synonyms: 1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine,97%;1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine, 97%;4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected;tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate;3-Fluoro-4-[4-(tert-butoxycarbonyl)piperazin-1-yl]nitrobenzene;1-Piperazinecarboxylic acid, 4-(2-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester
CBNumber: CB11261843
Molecular Formula: C15H20FN3O4
Formula Weight: 325.34
MOL File: 154590-34-8.mol

More

Less

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Property

Melting point:: 153-155 °C(Solv: ethyl ether (60-29-7))
Boiling point:: 453.5±45.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: Solid
pka: 0.11±0.10(Predicted)
Appearance: Light yellow to yellow Solid
CAS DataBase Reference: 154590-34-8

More

Less

Safety

HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-M3038
Product name: 3-Fluoro-4-[4-(tert-butoxycarbonyl)piperazin-1-yl]nitrobenzene
Packaging: 1g
Price: $57
Updated: 2021/12/16

AK Scientific

Product number: Z4208
Product name: tert-Butyl4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate
Packaging: 1g
Price: $151
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-3-44
Product name: 4-(2-Fluoro-4-nitrophenyl)piperazine, N1-Boc protected
Packaging: 1g
Price: $151
Updated: 2021/12/16

Apolloscientific

Product number: PC8776
Product name: 4-(2-Fluoro-4-nitrophenyl)piperazine,N1-BOCprotected
Packaging: 5g
Price: $174
Updated: 2021/12/16

Matrix Scientific

Product number: 046130
Product name: tert-Butyl 4-(2-fluoro-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $181
Updated: 2021/12/16

More

Less

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

154590-33-7

154590-34-8

General procedure for the synthesis of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate: 1. 1-(2-fluoro-4-nitrophenyl)piperazine (12.5 g, 55.8 mmol) was dissolved in 1,4-dioxane (108 mL) under cooling conditions in an ice bath. 2. 1N sodium hydroxide solution (54 mL) and di-tert-butyl dicarbonate (14 mL, 61.38 mmol) were added sequentially to the above solution. 3. The temperature of the reaction mixture was adjusted to 25-35°C and stirred continuously for 0.5 hours. 4. Upon completion of the reaction, the mixture was poured into ice-cold water (200 mL) and a yellow precipitate was precipitated. 5. The precipitate was collected by filtration through a Büchner funnel to afford the target product tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (18.0 g, 99% yield). Product characterization data: 1H NMR (CDCl3): δ 8.01-7.88 (m, 2H), 6.93 (t, J = 8.6 Hz, 1H), 3.61 (t, J = 4.9 Hz, 4H), 3.24 (t, J = 4.9 Hz, 4H), 1.49 (s, 9H). IR (KBr, cm-1): 3119, 1692, 1605, 1512. CI-MS (m/z): 326 (M++1), 270, 240, 226, 195, 183, 131, 96.

References

[1] Patent: WO2005/82892, 2005, A2. Location in patent: Page/Page column 61
[2] Patent: CN107033095, 2017, A. Location in patent: Paragraph 0085; 0086
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 19, p. 4261 - 4267
[4] Patent: US2004/220194, 2004, A1. Location in patent: Page 13; 14
[5] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 18

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Suppliers

China 35 India 2 United Kingdom 1 United States 6 Global 44

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2151
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Run-Biotech Co., Ltd.

Tel: 021-57171705 13817537615
Fax: QQ3095748324
Email: sales@run-biotech.com
Country: China
ProdList: 2334
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

154590-34-8, tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylateRelated Search:

FLUPENTIXOL IMPURITY F Haloperidol

4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine, 97%

3-Fluoro-4-[4-(tert-butoxycarbonyl)piperazin-1-yl]nitrobenzene

1-Piperazinecarboxylic acid, 4-(2-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester

1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine,97%

154590-34-8