1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)

Product Name: 1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
CAS No.: 194278-45-0
Chemical Name: 1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
Synonyms: 3-Methyl-1H-pyrazolo[4,3-...;3-methyl-2h-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 3-methyl-;1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
CBNumber: CB11274524
Molecular Formula: C7H7N3
Formula Weight: 133.15
MOL File: 194278-45-0.mol

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1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Property

Boiling point:: 290.1±20.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 11.33±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M219333
Product name: 3-Methyl-1H-pyrazolo[4,3-b]pyridine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-W021962
Product name: 3-Methyl-1H-pyrazolo[4,3-b]pyridine
Purity: 98.76%
Packaging: 1g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W4149
Product name: 3-Methyl-1H-pyrazolo[4,3-b]pyridine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-1-31
Product name: 3-Methyl-1H-pyrazolo[4,3-b]pyridine
Packaging: 250mg
Price: $360
Updated: 2021/12/16

Matrix Scientific

Product number: 068784
Product name: 3-Methyl-1H-pyrazolo[4,3-b]pyridine
Purity: >95%
Packaging: 250mg
Price: $435
Updated: 2021/12/16

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1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Chemical Properties,Usage,Production

Synthesis

87674-20-2

194278-45-0

General procedure for the synthesis of 3-methyl-1H-pyrazolo[4,3-b]pyridine from 2-acetyl-3-fluoropyridine: 1-(3-fluoropyridin-2-yl)ethanone (1.00 g, 7.19 mmol) was dissolved in hydrazine monohydrate (12 mL, 247.00 mmol), which was heated in a microwave reactor for 3 hours at 130 °C. Upon completion of the reaction, water (50 mL) was added to dilute the reaction mixture and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification by a Biotage fast chromatography system (using a SNAP 50g silica gel column with ethyl acetate/ethanol as eluent, with the ratio tapered from 95/5 to 70/30) gave a cream-colored solid product (575 mg, 60% yield). The product was identified by 1H NMR (500 MHz, DMSO-d6): δ 12.87 (broad single peak, 1H), 8.46 (double peak, J = 4.3, 1.4 Hz, 1H), 7.91 (double peak, J = 8.5, 1.4 Hz, 1H), 7.33 (double peak, J = 8.5, 4.3 Hz, 1H), 2.53 (single peak, 3H). 13C NMR (126 MHz, DMSO-d6) δ 144.51, 142.04, 139.94, 133.42, 121.12, 118.49, 11.24. LCMS (Method M) retention time 0.52 min, [M + H]+ 134; HRMS calculated value C7H8N3: 134.0718, measured value: 134.0726.

References

[1] Patent: WO2016/26549, 2016, A1. Location in patent: Page/Page column 68-69

1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Suppliers

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