ChemicalBook > CAS DataBase List > 1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)

1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)

Product Name
1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
CAS No.
194278-45-0
Chemical Name
1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
Synonyms
3-Methyl-1H-pyrazolo[4,3-...;3-methyl-2h-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 3-methyl-;1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
CBNumber
CB11274524
Molecular Formula
C7H7N3
Formula Weight
133.15
MOL File
194278-45-0.mol
More
Less

1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Property

Boiling point:
290.1±20.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
11.33±0.40(Predicted)
Appearance
White to off-white Solid
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
M219333
Product name
3-Methyl-1H-pyrazolo[4,3-b]pyridine
Packaging
500mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-W021962
Product name
3-Methyl-1H-pyrazolo[4,3-b]pyridine
Purity
98.76%
Packaging
1g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W4149
Product name
3-Methyl-1H-pyrazolo[4,3-b]pyridine
Packaging
100mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-1-31
Product name
3-Methyl-1H-pyrazolo[4,3-b]pyridine
Packaging
250mg
Price
$360
Updated
2021/12/16
Matrix Scientific
Product number
068784
Product name
3-Methyl-1H-pyrazolo[4,3-b]pyridine
Purity
>95%
Packaging
250mg
Price
$435
Updated
2021/12/16
More
Less

1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Chemical Properties,Usage,Production

Synthesis

87674-20-2

194278-45-0

General procedure for the synthesis of 3-methyl-1H-pyrazolo[4,3-b]pyridine from 2-acetyl-3-fluoropyridine: 1-(3-fluoropyridin-2-yl)ethanone (1.00 g, 7.19 mmol) was dissolved in hydrazine monohydrate (12 mL, 247.00 mmol), which was heated in a microwave reactor for 3 hours at 130 °C. Upon completion of the reaction, water (50 mL) was added to dilute the reaction mixture and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification by a Biotage fast chromatography system (using a SNAP 50g silica gel column with ethyl acetate/ethanol as eluent, with the ratio tapered from 95/5 to 70/30) gave a cream-colored solid product (575 mg, 60% yield). The product was identified by 1H NMR (500 MHz, DMSO-d6): δ 12.87 (broad single peak, 1H), 8.46 (double peak, J = 4.3, 1.4 Hz, 1H), 7.91 (double peak, J = 8.5, 1.4 Hz, 1H), 7.33 (double peak, J = 8.5, 4.3 Hz, 1H), 2.53 (single peak, 3H). 13C NMR (126 MHz, DMSO-d6) δ 144.51, 142.04, 139.94, 133.42, 121.12, 118.49, 11.24. LCMS (Method M) retention time 0.52 min, [M + H]+ 134; HRMS calculated value C7H8N3: 134.0718, measured value: 134.0726.

References

[1] Patent: WO2016/26549, 2016, A1. Location in patent: Page/Page column 68-69

1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI) Suppliers

China 48 Europe 1 India 1 United States 6 Global 56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

194278-45-0, 1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)Related Search:


  • 1H-Pyrazolo[4,3-b]pyridine,3-methyl-(9CI)
  • 3-Methyl-1H-pyrazolo[4,3-...
  • 3-methyl-2h-pyrazolo[4,3-b]pyridine
  • 1H-Pyrazolo[4,3-b]pyridine, 3-methyl-
  • 194278-45-0
  • Heterocycle-Pyridine series
  • PYRIDINE