Z-VAL-DL-ASP-FLUOROMETHYLKETONE

Product Name: Z-VAL-DL-ASP-FLUOROMETHYLKETONE
CAS No.: 582316-00-5
Chemical Name: Z-VAL-DL-ASP-FLUOROMETHYLKETONE
Synonyms: Z-VD-FMK;Z-Val-DL-Asp-FMK;Z-Val-Asp-Fluoromethyl Ketone;Z-VAL-DL-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP-FLUOROMETHYL KETONE;Z-VD-FMK;3-({N-[(Benzyloxy)Carbonyl]-L-Valyl}Amino)-5-Fluoro-4-Oxopentanoic Acid;3-((S)-2-(((Benzyloxy)carbonyl)aMino)-3-MethylbutanaMido)-5-fluoro-4-oxopentanoic acid;Pentanoic acid,5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-
CBNumber: CB1128033
Molecular Formula: C18H23FN2O6
Formula Weight: 382.38
MOL File: 582316-00-5.mol

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Z-VAL-DL-ASP-FLUOROMETHYLKETONE Property

Boiling point:: 639.8±55.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 10 mg/ml
form: A solid
pka: 3.92±0.19(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27904
Product name: MX1013
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 27904
Product name: MX1013
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 27904
Product name: MX1013
Packaging: 25mg
Price: $268
Updated: 2024/03/01

BroadPharm

Product number: BP-22470
Product name: Z-Val-Asp-FluoromethylKetone
Purity: 96%
Packaging: 25mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 3350CR
Product name: 3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoicacid
Packaging: 10mg
Price: $233
Updated: 2021/12/16

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Z-VAL-DL-ASP-FLUOROMETHYLKETONE Chemical Properties,Usage,Production

Uses

MX1013 is a potent, irreversible dipeptide caspase inhibitor vith?antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50?of 30 nM[1].

in vivo

MX1013 is an effective antiapoptotic agent?in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects^[1].

Animal Model:	Female ND4 Swiss Webster mice (16.5-21 g)^[1]
Dosage:	0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm?Tris-HCl, pH 8.0)
Administration:	Injected i.v.
Result:	The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg?dose protected 100% of the mice at the 3 h time point.

IC 50

Caspase

References

[1] Wu Yang,?et al. MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity. Br J Pharmacol.?2003 Sep;140(2):402-12. DOI:10.1038/sj.bjp.0705450

Z-VAL-DL-ASP-FLUOROMETHYLKETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-VAL-DL-ASP-FLUOROMETHYLKETONE Suppliers

China 24 United States 8 Global 32

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582316-00-5, Z-VAL-DL-ASP-FLUOROMETHYLKETONERelated Search:

Z-VAL-DL-ASP-FLUOROMETHYLKETONE Z-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE CASPASE INHIBITOR IX

Z-VAL-DL-ASP-FLUOROMETHYLKETONE

Z-VD-FMK

Pentanoic acid,5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-

3-((S)-2-(((Benzyloxy)carbonyl)aMino)-3-MethylbutanaMido)-5-fluoro-4-oxopentanoic acid

Z-Val-Asp-Fluoromethyl Ketone

Z-VAL-ASP-FLUOROMETHYL KETONE;Z-VD-FMK

3-({N-[(Benzyloxy)Carbonyl]-L-Valyl}Amino)-5-Fluoro-4-Oxopentanoic Acid

Z-Val-DL-Asp-FMK

582316-00-5

C18H23FN2O6

An irreversible general caspase inhibitor.